Veterinary tuberculosis vaccine development
Veterinary tuberculosis vaccine development
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DOI：
10.1086/313865
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发表时间：
2000-06-01
影响因子：
11.8
通讯作者：
Griffin, JFT
中科院分区：
文献类型：
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作者：
Griffin, JFT
牛分枝杆菌在家畜和野生动物中引起的结核病在世界许多国家都是一个严重的问题。野生动物结核病宿主扰乱了从家畜中根除结核病的计划。在家畜或野生动物中成功接种结核病疫苗可有助于根除结核病。卡介苗(BCG)已被用作家畜和野生动物的疫苗原型。大多数研究都是在接种了卡介苗的动物身上进行的，实验中挑战了牛分支杆菌。尽管对疾病的保护在所有这些研究中都很明显，但对感染的保护很少发生。本文介绍了对牛、鹿、雪貂、负鼠和兔子进行卡介苗接种所获得的结果，强调了接种和控制影响卡介苗效力的变量的适当动物模型的必要性。现有动物模型的改进对于推进与动物和人类相关的结核病疫苗研究至关重要。
Tuberculosis caused by Mycobacterium bovis in domestic livestock and wildlife is a significant problem in many countries worldwide. Wildlife reservoirs of tuberculosis confound programs for tuberculosis eradication from domestic livestock. Successful vaccination against tuberculosis in domestic animals or wildlife could contribute to tuberculosis eradication. Bacille Calmette-Guerin (BCG) has been used as the prototype vaccine for domestic livestock and wildlife. The majority of studies have been carried out with BCG-vaccinated animals challenged experimentally with M, bovis. Although protection against disease has been evident in all these studies, protection against infection has rarely occurred. Results obtained with BCG vaccination of cattle, deer, ferrets, opossums, and rabbits are presented here and highlight the need for appropriate animal models for vaccination and control of the variables that influence the efficacy of BCG vaccine. Refinement of the existing animal models is essential for the advancement of tuberculosis vaccine research of relevance to animals and humans.