Synaptic organization of the rat thalamus: a quantitative study
Synaptic organization of the rat thalamus: a quantitative study
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DOI：
10.1007/s10072-011-0606-4
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发表时间：
2011-12-01
影响因子：
3.3
通讯作者：
Onat, Filiz
中科院分区：
文献类型：
--
作者：
Cavdar, Safiye;Hacioglu, Husniye;Onat, Filiz
丘脑一级核团接受来自上行通路的驱动传入，并将处理后的信息传递到皮层。高级丘脑核团接收来自皮层第5层的驱动信息，并将信息从一个皮层区域传递到另一个皮层区域。本文比较了大鼠丘脑三个一级核（腹基底核、外侧膝状体核和前腹核）和三个高级核（后核、外侧后核和中背核）中不同类型的轴突终末RL（圆形小泡、大终末）、RS（圆形小泡、小终末）和F（扁平小泡）及其突触连接。在本研究中，高阶继电器不同于一阶继电器，如猫，在有更少的驱动终端（RL）和突触比一阶继电器。然而，F终端显示相反的比例在第一与高阶丘脑核。在所研究的所有丘脑核中，大多数终末都是RS终末。三种类型的终末面积和突触长度的测量结果表明，一级和高级核之间没有显着差异。在所有丘脑核团中，驱动输入代表少数，而调制输入代表大多数终末和突触。总之，有一个相对缺乏的驱动输入，而调制输入建立更多的突触，以实现更精细的调制。
First-order thalamic nuclei receive driving afferents from ascending pathways and transmit processed information to the cortex. Higher-order thalamic nuclei receive driver messages from layer 5 of cortex and transmit information from one cortical area to the other. The different types of axon terminals RL (round vesicles, large terminals), RS (round vesicles, small terminals) and F (flattened vesicles) and their synaptic junctions have been here compared in three first-order (ventrobasal, lateral geniculate and anteroventral) and three higher-order (posterior, lateral posterior and mediodorsal) thalamic nuclei of the rat. In the present study, the higher-order relays differ from first-order relays as in the cat, in having fewer driver terminals (RL) and synapses than do the first-order relays. However, the F terminals showed opposite ratios in the first versus higher-order thalamic nuclei. The majority of the terminals in all thalamic nuclei studied were RS terminals. The area measurements of the three types of terminals and synaptic lengths showed no significant differences between first and higher-order nuclei. The driver inputs represent the minority and the modulatory inputs represent the majority of the terminals and synapses in all thalamic nuclei. In conclusion, there is a relative paucity of driver inputs, whereas modulatory inputs establish more numerous synapses to achieve finer modulation.