A computational study of the effect of capillary network anastomoses and tortuosity on oxygen transport
A computational study of the effect of capillary network anastomoses and tortuosity on oxygen transport
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DOI：
10.1006/jtbi.2000.2113
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发表时间：
2000-09-21
影响因子：
2
通讯作者：
Popel, AS
中科院分区：
文献类型：
--
作者：
Goldman, D;Popel, AS
本研究的目的是探讨毛细血管网的闭塞和曲折对骨骼肌氧转运的影响，以及肌纤维在决定平行毛细血管排列中的重要性。还研究了逆流流动和随机毛细血管阻塞（例如，被白色血细胞阻塞）。构建了一个通用的计算模型，以模拟从矩形组织体积内的血管网络的氧气输送。毛细血管网络结构的几何模型，六边形包装的肌纤维的基础上，被构造成产生直的无分支的毛细血管，毛细血管与血管瘤，和曲折的毛细血管的网络，以检查这些几何特性的影响。检测组织氧分压和毛细血管血氧饱和度。计算模型包括血流的两相模拟。选择合适的参数用于工作仓鼠颊袋牵开肌。我们的计算表明，肌肉纤维的几何形状是重要的，在减少氧气运输的异质性，是逆流如何。发现迂曲可增加组织氧合，特别是与纤维蛋白酶结合时。在不存在迂曲的情况下，在正常条件下，动脉粥样硬化对氧转运的影响很小，但在血管阻塞时，动脉粥样硬化显著改善了氧转运。(C)北京大学出版社.
The objective of this study was to investigate the effects of capillary network anastomoses and tortuosity on oxygen transport in skeletal muscle, as well as the importance of muscle fibers in determining the arrangement of parallel capillaries. Countercurrent flow and random capillary blockage (e.g. by white blood cells) were also studied. A general computational model was constructed to simulate oxygen transport from a network of blood vessels within a rectangular volume of tissue. A geometric model of the capillary network structure, based on hexagonally packed muscle fibers, was constructed to produce networks of straight unbranched capillaries, capillaries with anastomoses, and capillaries with tortuosity, in order to examine the effects of these geometric properties. Quantities examined included the tissue oxygen tension and the capillary oxyhemoglobin saturation. The computational model included a two-phase simulation of blood flow. Appropriate parameters were chosen for working hamster cheek-pouch retractor muscle. Our calculations showed that the muscle-fiber geometry was important in reducing oxygen transport heterogeneity, as was countercurrent how. Tortuosity was found to increase tissue oxygenation, especially when combined with anastomoses. In the absence of tortuosity, anastomoses had little effect on oxygen transport under normal conditions, but significantly improved transport when vessel blockages were present. (C) 2000 Academic Press.