The Cerebellar Cortex Receives Orofacial Proprioceptive Signals from the Supratrigeminal Nucleus via the Mossy Fiber Pathway in Rats
The Cerebellar Cortex Receives Orofacial Proprioceptive Signals from the Supratrigeminal Nucleus via the Mossy Fiber Pathway in Rats
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大鼠小脑皮层通过苔藓纤维通路接收来自三叉神经上核的口面本体感觉信号
DOI：
10.1007/s12311-022-01434-z
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Yoshida Atsushi
中科院分区：
文献类型：
--
作者：
Tsutsumi Yumi;Sato Fumihiko;Furuta Takahiro;Uchino Katsuro;Moritani Masayuki;Bae Yong Chul;Kato Takafumi;Tachibana Yoshihisa;Yoshida Atsushi
来自肌梭的本体感觉信息对于运动功能的调节是必不可少的。然而，人们对小脑皮质中的运动控制区知之甚少，这些区域从分布在全身的肌梭接收本体感觉信号，包括口面部肌肉。因此，在本研究中，我们研究了来自三叉神经上核(Su5)的大鼠小脑皮质内的投射模式，该核从闭合性肌梭(JCMS)传递口面部本体感觉信息。向Su5区注入顺行示踪剂后，在小脑皮质的颗粒层(包括单叶B小叶、小腿II和小叶小叶)可见许多双侧轴突终末(玫瑰花结)呈大小不等的多片状分布。我们还可以在这些小脑皮质区域检测到JCMS本体感觉信号，首次揭示它们在大鼠体内接受肌肉本体感觉输入。逆行示踪剂注射证实，Su5直接将输出信号发送到小脑皮质区域。此外，我们将顺行示踪剂注射到楔状外核(ECU)，该ECU接收来自前肢和颈部肌梭的本体感受信号，以区分小脑皮质中Su5和ECU来源的投射。来自ECU的标记终末主要分布在小脑皮质的蠕虫内。在Su5和ECU投影的末端分布中几乎没有看到重叠。我们的发现表明，大鼠小脑皮质接受口面部本体感觉输入，其处理方式与来自身体其他区域的本体感觉信号不同。
Proprioceptive sensory information from muscle spindles is essential for the regulation of motor functions. However, little is known about the motor control regions in the cerebellar cortex that receive proprioceptive signals from muscle spindles distributed throughout the body, including the orofacial muscles. Therefore, in this study, we investigated the pattern of projections in the rat cerebellar cortex derived from the supratrigeminal nucleus (Su5), which conveys orofacial proprioceptive information from jaw-closing muscle spindles (JCMSs). Injections of an anterograde tracer into the Su5 revealed that many bilateral axon terminals (rosettes) were distributed in the granular layer of the cerebellar cortex (including the simple lobule B, crus II and flocculus) in a various sized, multiple patchy pattern. We could also detect JCMS proprioceptive signals in these cerebellar cortical regions, revealing for the first time that they receive muscle proprioceptive inputs in rats. Retrograde tracer injections confirmed that the Su5 directly sends outputs to the cerebellar cortical areas. Furthermore, we injected an anterograde tracer into the external cuneate nucleus (ECu), which receives proprioceptive signals from the forelimb and neck muscle spindles, to distinguish between the Su5- and ECu-derived projections in the cerebellar cortex. The labeled terminals from the ECu were distributed predominantly in the vermis of the cerebellar cortex. Almost no overlap was seen in the terminal distributions of the Su5 and ECu projections. Our findings demonstrate that the rat cerebellar cortex receives orofacial proprioceptive input that is processed differently from the proprioceptive signals from the other regions of the body.
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DOI：
--
发表时间：
1999
期刊：
The Journal of comparative neurology
影响因子：
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作者：
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DOI：
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发表时间：
--
期刊：
影响因子：
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作者：
通讯作者：
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DOI：
--
发表时间：
1988
期刊：
Neurosciences research
影响因子：
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C. Buisseret‐Delmas
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DOI：
--
发表时间：
1987
期刊：
The Journal of comparative neurology
影响因子：
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作者：
L. Jasmin;J. Courville
通讯作者：
J. Courville