Feasibility and Parent Satisfaction of a Physical Therapy Intervention Program for Children With Acute Lymphoblastic Leukemia in the First 6 Months of Medical Treatment
Feasibility and Parent Satisfaction of a Physical Therapy Intervention Program for Children With Acute Lymphoblastic Leukemia in the First 6 Months of Medical Treatment
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DOI：
10.1002/pbc.22713
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发表时间：
2011-05-01
影响因子：
3.2
通讯作者：
Marchese, Victoria
中科院分区：
文献类型：
--
作者：
Gohar, Shadi Farzin;Comito, Melanie;Marchese, Victoria
背景患有急性淋巴细胞白血病（ALL）的儿童在治疗期间和治疗后有发生肌肉骨骼并发症的风险。本研究的目的是检查在前四个阶段的医疗，新诊断的急性淋巴细胞白血病的儿童在医院的物理治疗和家庭锻炼计划的可行性。Procedure. 9名年龄在2-14岁之间的患者在诊断后2周内入组研究。每例患者在研究入组时、前四个治疗阶段后以及每次患者再次入院时进行评价。在最初的物理治疗评估之后，制定了个性化的家庭锻炼计划，包括拉伸，强化和有氧运动。在每次评估时测量以下终点：通过粗大运动功能测量（GMFM）测量的粗大运动评估，通过PedsQL和父母满意度问卷测量的健康相关生活质量。结果该研究是可行的，98%的评价会议完成。在整个研究期间，GMFM和PedsQL稳步改善;但是，从中期维持治疗到延迟强化治疗，PedsQL略有下降。父母对物理治疗计划表示满意。结论我们证明，在医疗治疗的前四个阶段进行住院和家庭运动物理治疗计划对于ALL儿童是可行的。需要进一步的随机研究来确认ALL儿童诊断时的初始物理治疗计划是否会限制功能障碍，改善整体健康状况并提高健康相关的生活质量。小儿血癌。2011;56：799-804. (c)2011 Wiley-Liss，Inc.
Background. Children with acute lymphoblastic leukemia (ALL) are at risk for developing musculoskeletal complications during and after their medical treatment. The objective of this study was to examine the feasibility of an in-hospital physical therapy- and home exercise program during the first four phases of medical treatment, for children with newly diagnosed ALL. Procedure. Nine patients, between the ages of 2-14 years old were enrolled within 2 weeks of diagnosis in the study. Each patient was evaluated at study entry, after each of the first four phases of therapy and each time patients were re-admitted to the hospital. Following the initial physical therapy evaluation an individualized home exercise program was developed, consisting of stretching, strengthening, and aerobic exercises. The following end points were measured at each evaluation: gross motor assessment as measured by gross motor function measure (GMFM), health-related quality of life as measured by the PedsQL and parent satisfaction questionnaire. Results. This study was feasible with 98% of the evaluation sessions completed. The GMFM and PedsQL improved steadily throughout the study; however, the PedsQL slightly decreased from interim maintenance to delayed intensification. The parents reported being satisfied with the physical therapy program. Conclusion. We demonstrated that an in-hospital- and home exercise physical therapy program during the first four phases of medical treatments is feasible for children with ALL. Future randomized studies are needed to confirm whether an initial physical therapy program at diagnosis in children with ALL will limit functional impairments, improve overall fitness and increase health-related quality of life. Pediatr Blood Cancer. 2011;56:799-804. (c) 2011 Wiley-Liss, Inc.