A new sterol from the Vietnamese marine sponge Xestospongia testudinaria and its biological activities
A new sterol from the Vietnamese marine sponge Xestospongia testudinaria and its biological activities
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DOI：
10.1080/14786419.2018.1465057
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发表时间：
2019-04
影响因子：
2.2
通讯作者：
H. Nguyen;Takuya Ito;N. Win;H. Vo;H. Nguyen;H. Morita
中科院分区：
文献类型：
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作者：
H. Nguyen;Takuya Ito;N. Win;H. Vo;H. Nguyen;H. Morita
摘要 从越南采集的海生海绵 Xestospongia testudinaria 中分离出一种新的甾醇 langcosterol A (1) 以及两种已知的甾醇 2 和 3。它们的化学结构是在广泛的光谱分析和与已发表数据的比较的基础上阐明的。新化合物1和已知化合物3对三种人类癌细胞系（A549，肺癌；MCF7，乳腺癌；HeLa，宫颈癌）和人类正常细胞系（WI-38成纤维细胞）表现出中等的细胞毒活性，IC50值范围为29.0至68.0 μM。
Abstract A new sterol, langcosterol A (1), together with two known sterols 2 and 3, were isolated from the marine sponge Xestospongia testudinaria collected in Vietnam. Their chemical structures were elucidated on the basis of extensive spectroscopic analyses and comparisons with published data. The new compound 1 and the known compound 3 exhibited moderate cytotoxic activities against three human cancer cell lines (A549, lung cancer; MCF7, breast cancer; HeLa, cervical cancer) and a human normal cell line (WI-38 fibroblast), with IC50 values ranging from 29.0 to 68.0 μM.