The idiopathic forms of premature menopause and early menopause show the same genetic pattern
The idiopathic forms of premature menopause and early menopause show the same genetic pattern
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DOI：
10.1093/humrep/14.11.2731
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发表时间：
1999-11-01
影响因子：
6.1
通讯作者：
Crosignani, PG
中科院分区：
文献类型：
--
作者：
Tibiletti, MG;Testa, G;Crosignani, PG
遗传因素可能会影响更年期的时间。卵巢早衰（POF）最近已被确定为一种遗传实体，但没有关于绝经早期（EM）的遗传数据。我们调查了36例EM患者（绝经年龄在40至45岁之间），采用细胞遗传学和系谱分析。在本研究的30例患者中，EM是特发性的，15例受试者（50%）有EM或POF的家族性疾病。系谱分析显示EM的遗传方式主要是通过母系或父系亲属。我们的数据显示，POF和EM患者表现出相同的遗传特征，我们假设这些条件可能是同一种遗传疾病的可变表达。
Genetic factors may influence the timing of menopause. Premature ovarian failure (POF) has recently been identified as a genetic entity, but no genetic data are available on early menopause (EM). We investigated 36 patients with EM (age of menopause between 40 and 45 years of age) using cytogenetic and pedigree analysis. In 30 patients of this study the EM was idiopathic and 15 subjects (50%) had a familial condition of EM or POF. Pedigree analysis revealed a dominant pattern of inheritance of EM through maternal or paternal relatives. Our data reveal that POF and EM patients show the same genetic features and we postulate that these conditions may be a variable expression of the same genetic disease.