Comparison of polychlorinated biphenyl levels across studies of human neurodevelopment
Comparison of polychlorinated biphenyl levels across studies of human neurodevelopment
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DOI：
10.1289/ehp.5463
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发表时间：
2003-01-01
影响因子：
10.4
通讯作者：
Jensen, AA
中科院分区：
文献类型：
--
作者：
Longnecker, MP;Wolff, MS;Jensen, AA
多氯联苯（PCBs）是食物链中普遍存在的持久性污染物，在大多数接受检查的人群中，几乎每个人的血液中都有可检测到的含量。动物研究的大量证据表明，多氯联苯是神经毒素，即使在低剂量下也是如此。关于低水平，早期生活的PCB暴露和随后的神经发育的人类数据的解释是有问题的，因为暴露水平没有类似的量化跨研究。我们使用原始研究者的数据、实验室再分析、基于已发表数据的计算和专家意见，以统一的方式表达了10项PCB和神经发育研究的暴露水平。我们比较的主要依据是孕妇妊娠血清中PCB 153的中位数水平。10项研究中PCB 153的中位浓度范围为30 - 450 ng/g血清脂质，10项中位值为110 ng/g。我们发现，a）大多数研究中PCB 153暴露的分布基本重叠，B）法罗群岛研究中的暴露水平比大多数其他研究高出3-4倍，c）最近两项美国研究中的暴露水平约为美国早期四项研究或荷兰、德国和北方魁北克最近研究的三分之一。我们的研究结果将有助于直接比较PCB和神经发育的研究结果时，他们发表的所有10项研究。
Polychlorinated biphenyls (PCBs) are persistent pollutants that are ubiquitous in the food chain, and detectable amounts are in the blood of almost every person in most populations that have been examined. Extensive evidence from animal studies shows that PCBs are neurotoxins, even at low doses. Interpretation of human data regarding low-level, early-life PCB exposure and subsequent neurodevelopment is problematic because levels of exposure were not similarly quantified across studies. We expressed the exposure levels from 10 studies of PCB and neurodevelopment in a uniform manner using a combination of data from original investigators, laboratory reanalyses, calculations based on published data, and expert opinion. The mainstay of our comparison was the median level of PCB 153 in maternal pregnancy serum. The median concentration of PCB 153 in the 10 studies ranged from 30 to 450 ng/g serum lipid, and the median of the 10 medians was 110 ng/g. We found that a) the distribution of PCB 153 exposure in most studies overlapped substantially, b) exposure levels in the Faroe Islands study were about 3-4-fold higher than in most other studies, and c) the exposure levels in the two recent U.S. studies were about one-third of those in the four earlier U.S. studies or recent Dutch, German, and northern Quebec studies. Our results will facilitate a direct comparison of the findings on PCBs and neurodevelopment when they are published for all 10 studies.