Genetic interactions between transcription factors cause natural variation in yeast.
Genetic interactions between transcription factors cause natural variation in yeast.
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DOI：
10.1126/science.1166426
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发表时间：
2009-01-23
期刊：
影响因子：
--
通讯作者：
Cohen B
中科院分区：
文献类型：
--
作者：
Gerke J;Lorenz K;Cohen B
我们对表型多样性的遗传基础的理解受到已经确定的多个相互作用位点的例子的缺乏的限制。我们发现，橡树和葡萄园菌株之间产孢效率（酵母中启动生命周期性阶段的程序）的自然差异是由于三种转录因子（IME1、RME1和RSF1）的四个核苷酸变化之间的等位基因差异。此外，我们发现，选择已经形成了菌株之间酵母菌产孢量的变化。这些结果说明了转录因子之间的遗传相互作用是物种内表型多样性的主要来源。
Our understanding of the genetic basis of phenotypic diversity is limited by the paucity of examples in which multiple, interacting loci have been identified. We show that natural variation in the efficiency of sporulation, the program in yeast that initiates the sexual phase of the life cycle, between oak tree and vineyard strains is due to allelic variation between four nucleotide changes in three transcription factors: IME1, RME1, and RSF1. Furthermore, we identified that selection has shaped quantitative variation in yeast sporulation between strains. These results illustrate how genetic interactions between transcription factors are a major source of phenotypic diversity within species.