CYTOCHALASANS - NEW CLASS OF BIOLOGICALLY-ACTIVE MICROBIAL METABOLITES
CYTOCHALASANS - NEW CLASS OF BIOLOGICALLY-ACTIVE MICROBIAL METABOLITES
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DOI：
10.1002/anie.197303701
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发表时间：
1973-01-01
影响因子：
16.6
通讯作者：
TAMM, C
中科院分区：
文献类型：
--
作者：
BINDER, M;TAMM, C
近年来，从微生物中分离出一系列具有细胞抑制活性的代谢物。这些化合物在化学上密切相关，是一种新的结构类型。一个高度取代的氢化异吲哚单元被融合到一个11到14个成员的大环中。大环可以是碳环或杂环(内酯或碳二酯)。通过X-射线分析确定了两种细胞松弛素(Phomin和细胞松弛素D衍生物)的绝对构型。Phomin(细胞松弛素B)的生物发生是广为人知的，所有的细胞松弛素可能都有一个共同的生物发生方案。所有这类化合物都或多或少具有明显的特定细胞抑制作用。
A series of cytostatically active metabolites have been isolated from microorganisms in recent years. These compounds, which are chemically closely related, are of a new structural type. A highly substituted hydrogenated isoindolone unit is fused to an 11‐ to 14‐membered macrocycle. The large ring may be carbocyclic or heterocyclic (lactone or carbonic diester). The absolute configurations of two cytochalasans (phomin and a cytochalasin D derivative) have been established by X‐ray analysis. The biogenesis of phomin (cytochalasin B) is broadly known, and it is probable that all cytochalasans have a common biogenetic scheme. All the compounds of this class have a more or less pronounced specifically cytostatic action.