Antibody production and protection against influenza virus in immunodeficient mice
Antibody production and protection against influenza virus in immunodeficient mice
复制标题
免疫缺陷小鼠的抗体产生和针对流感病毒的保护
作者：
S. J. Lucas;D. Barry;P. Kind
通过使用T细胞（无胸腺裸）或免疫球蛋白产生（CBA/N）缺陷的小鼠来研究T和B细胞在对流感病毒的免疫应答中的作用。检查了这些小鼠对完整或破碎的A/Aichi/2/68流感病毒疫苗的血清学应答，并通过用小鼠适应的A/Aichi/2/68流感病毒攻击感染来测试这些接种的保护作用。与正常小鼠相反，免疫缺陷小鼠接种任何一种疫苗后均未产生可检测的血清抗体。CBA/N小鼠用完整的病毒疫苗免疫，但是，对随后的致死性攻击的保护。接种破碎病毒疫苗的CBA/N小鼠和接种破碎病毒疫苗或全病毒疫苗的裸小鼠均不能抵抗病毒攻击。在灭活疫苗免疫后存活的CBA/N和裸小鼠中观察到免疫记忆的证据。
The roles of T and B cells in the immune response to influenza virus were studied by using mice deficient in either T cells (athymic nude) or immunoglobulin production (CBA/N). The serological responses of these mice to either whole or disrupted A/Aichi/2/68 influenza virus vaccines were examined, and the protective effect of these inoculations was tested by challenge infection with mouse-adapted A/Aichi/2/68 influenza virus. In contrast to normal mice, neither strain of immunodeficient mouse produced detectable serum antibody after inoculation with either type of vaccine. CBA/N mice immunized with intact virus vaccine were protected, however, against subsequent lethal challenge. CBA/N mice inoculated with disrupted virus vaccine and nude mice inoculated with either disrupted or whole virus vaccine were not protected against viral challenge. Evidence of immunological memory was observed in CBA/N and nude mice that had survived live virus challenge after immunization with inactivated vaccine.
雪貂对流感的异型免疫。
影响因子：
3.1
作者：
Yetter,RA;Barber,WH;SmallJr,PA
通讯作者：
SmallJr,PA