Efficient palladium-catalyzed nucleophilic addition of triorganoindium reagents to carbocyclic derivatives
Efficient palladium-catalyzed nucleophilic addition of triorganoindium reagents to carbocyclic derivatives
复制标题
DOI：
10.1021/jo0357162
复制
发表时间：
2004-05-28
影响因子：
3.6
通讯作者：
Minehan, T
中科院分区：
文献类型：
--
作者：
Baker, L;Minehan, T
研究了钯（0）催化的三有机铟试剂的烯丙基取代反应。在1-3 mol % Pd-2（dba）（3）存在下，原位生成的乙烯基-和芳基铟与取代和未取代的环己-2-烯基酯反应，以中等至优异的产率生成乙烯基-或芳基环己烯。这个过程的立体选择性也进行了检查，并提出证据表明，该反应进行与立体化学构型的反转。
Palladium (0)-catalyzed allylic substitution reactions employing triorganoindium reagents have been investigated. In situ generated vinyl- and arylindiums react with substituted and unsubstituted cyclohex-2-enyl esters in the presence of 1-3 mol % Pd-2(dba)(3) to produce vinyl- or arylcyclohexenes in moderate to excellent yields. The stereoselectivity of this process was also examined, and evidence is presented that the reaction proceeds with inversion of stereochemical configuration.