Openness and conscientiousness predict 34-week patterns of Interleukin-6 in older persons
Openness and conscientiousness predict 34-week patterns of Interleukin-6 in older persons
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DOI：
10.1016/j.bbi.2011.01.003
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发表时间：
2011-05-01
影响因子：
15.1
通讯作者：
Moynihan, Jan
中科院分区：
文献类型：
--
作者：
Chapman, Benjamin P.;van Wijngaarden, Edwin;Moynihan, Jan
研究表明，性格可能与炎症标志物如白细胞介素（IL）-6有关。人格和IL-6之间的一种途径可能是健康行为和导致炎症的条件，而另一种途径涉及应激反应系统的激活。在200名老年人的临床试验样本中，我们研究了基线人格特质与IL-6三项指标之间的关联，随访时间为34周。结果表明，随着时间的推移，IL-6保持非常稳定，在整个34周期间，更高的责任心和开放性与较低的IL-6相关。在IL-6关联中，目标追求是责任心的活跃子成分，而审美兴趣是开放性的活跃子成分。常见的健康行为和慢性疾病仅占这些影响的一部分，这表明其他行为和/或生理过程也可能使一些人易患炎症。个性表型可能为炎症提供有用的预后信息。责任心和开放性较低的老年人是抗炎干预的目标人群。开放性和尽责性预测老年人白细胞介素-6的32周模式(C)2011 Elsevier Inc. All rights reserved.
Studies have indicated that personality may be associated with inflammatory markers such as Interleukin (IL)-6. One pathway between personality and IL-6 may be health behaviors and conditions resulting in inflammation, while an alternate pathway involves activation of stress-response systems. In a clinical trial sample of 200 older adults, we examined associations between personality traits at baseline and three measures of IL-6 spanning 34 weeks of follow-up. Results indicate that IL-6 remained very stable over time, and that higher Conscientiousness and Openness were associated with lower IL-6 across the entire 34 week period. Goal striving was the active subcomponent of Conscientiousness, while aesthetic interests was the active subcomponent of Openness in IL-6 associations. Common health behaviors and chronic illness accounted for only a portion of these effects, suggesting that other behavioral and/or physiological processes may also predispose some persons to inflammation. Personality phenotype may provide useful prognostic information for inflammation. Older adults lower in Conscientiousness and Openness constitute a target population for anti-inflammatory interventions. Openness and Conscientiousness predicts 32-week patterns of Interleukin-6 in older persons. (C) 2011 Elsevier Inc. All rights reserved.