Periodontitis and rheumatoid arthritis: A review
Periodontitis and rheumatoid arthritis: A review
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DOI：
10.1902/jop.2005.76.11-s.2066
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发表时间：
2005-11-01
影响因子：
4.3
通讯作者：
Haynes, DR
中科院分区：
文献类型：
--
作者：
Bartold, PM;Marshall, RI;Haynes, DR
牙周炎和类风湿性关节炎（RA）似乎有许多共同的病理特征。在这篇综述中，探讨了这两种常见慢性病的共同病理机制。现在新出现的证据表明，牙周病的范围和严重程度与 RA 之间存在密切关系。虽然这种关系不太可能是因果关系，但很明显，与非 RA 患者相比，患有晚期 RA 的个体更有可能经历更严重的牙周问题，反之亦然。有证据表明，这两种疾病可能通过基本炎症机制的共同潜在功能障碍而密切相关。这种功能障碍的性质仍然未知。尽管如此，越来越多的证据支持这样的观点，即这两种情况都是促炎细胞因子和抗炎细胞因子之间不平衡的结果。因此，预计会出现针对这两种疾病的新治疗策略，其目标可能是抑制促炎细胞因子和破坏性蛋白酶。当前数据的临床意义表明，应该仔细筛查 RA 患者的牙周状况。
Periodontitis and rheumatoid arthritis (RA) appear to share many pathologic features. In this review, the common pathologic mechanisms of these two common chronic conditions are explored. Emerging evidence now suggests a strong relationship between the extent and severity of periodontal disease and RA. While this relationship is unlikely to be causal, it is clear that individuals with advanced RA are more likely to experience more significant periodontal problems compared to their non-RA counterparts, and vice versa. A case is made that these two diseases could be very closely related through common underlying dysfunction of fundamental inflammatory mechanisms. The nature of such dysfunction is still unknown. Nonetheless, there is accruing evidence to support the notion that both conditions manifest as a result of an imbalance between proinflammatory and anti-inflammatory cytokines. As a result, new treatment strategies are expected to emerge for both diseases that may target the inhibition of proinflammatory cytokines and destructive proteases. The clinical implications of the current data dictate that patients with RA should be carefully screened for their periodontal status.