Deficits in Emotional and Social Cognition in Amyotrophic Lateral Sclerosis
Deficits in Emotional and Social Cognition in Amyotrophic Lateral Sclerosis
复制标题
DOI：
10.1037/a0020357
复制
发表时间：
2011-01-01
期刊：
影响因子：
2.4
通讯作者：
Abrahams, Sharon
中科院分区：
文献类型：
--
作者：
Girardi, Alessandra;MacPherson, Sarah E.;Abrahams, Sharon
目的：这些研究调查了非痴呆的ALS患者是否在情感决策和社会和情感认知测试中表现出障碍，对额叶变异型额颞叶痴呆（fvFTD）敏感。先前的研究表明，ALS中主要的执行功能障碍和背外侧前额叶受累，但其他前额叶功能障碍与fvFTD有关的证据很少。方法：研究A采用改良爱荷华州赌博任务（IGT）对19例ALS患者和20例健康对照者进行情感决策测验。行为测量包括额叶系统行为量表。在研究B中，14名ALS患者和20名对照者进行了社会和情感认知测试（基于眼睛凝视的偏好判断，眼中的心灵，面部表情的情感识别）。结果如下：在研究A中，ALS患者在TOT上表现出与健康对照组显著不同的表现特征，并且没有学会避免不利的刺激（区组3，d = 0.60，区组4天= 0.68）。行为评级显示从发病前水平增加冷漠。在研究B中，ALS患者在偏好判断任务的注意力要求（d = 3.12）和要求不高（d = 7.52）条件下受损，尽管许多患者显示出完整的执行功能。一个较小的子集表现出受损的情绪识别。行为变化也很明显。结论：研究结果显示，在一项简单的测试中，心理理论缺陷与执行功能障碍的存在无关，并提示提示亚临床fvFTD综合征的认知和行为功能障碍特征。前额叶通路的认知功能在ALS的相对贡献被认为是。
Objective: These studies investigated whether non-demented ALS patients display impairments on tests of emotional decision making and social and emotional cognition, sensitive to frontal variant Frontotemporal Dementia (fvFTD). Previous studies have shown predominant executive dysfunction and dorsolateral prefrontal involvement in ALS, but evidence of other prefrontal dysfunction implicated in fvFTD is sparse. Method: In Study A, 19 ALS patients and 20 healthy controls undertook a test of affective decision making, modified Iowa Gambling Task (IGT). Behavioral measures included the Frontal Systems Behavior Scale. In Study B, 14 ALS patients and 20 controls undertook tests of social and emotional cognition (Judgment of Preference based on eye gaze, the Mind in the Eyes, recognition of Facial Expressions of Emotion). Results: In Study A, ALS patients demonstrated a significantly different performance profile from healthy controls on the TOT and did not learn to avoid the disadvantageous stimuli (Block 3, d = 0.60, Block 4 days = 0.68). Behavior ratings showed increased apathy from premorbid levels. In Study B, ALS patients were impaired on attentionally demanding (d = 3.12) and undemanding (d = 7.52) conditions of the Judgment of Preference task, despite many showing intact executive functions. A smaller subset showed impaired emotion recognition. Behavior change was also evident. Conclusions: The findings reveal a Theory of Mind deficit on a simple test that was dissociated from the presence of executive dysfunction and suggests a profile of cognitive and behavioral dysfunction indicative of a subclinical fvFTD syndrome. The relative contribution of prefrontal pathways to the cognitive profile in ALS is considered.