MECHANISMS IN LACUNAR INFARCTION
MECHANISMS IN LACUNAR INFARCTION
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DOI：
10.1161/01.str.23.3.325
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发表时间：
1992-03-01
期刊：
影响因子：
8.3
通讯作者：
RUDOLPH, SH
中科院分区：
文献类型：
--
作者：
HOROWITZ, DR;TUHRIM, S;RUDOLPH, SH
背景和目的：腔隙被认为是高血压或糖尿病患者小血管病变的结果。 本研究评估了其他中风机制的重要性，在人口的腔隙性infarct.Methods：我们评估了108例连续患者的腔隙性分布的其他中风危险因素，如颈动脉和心脏diseases.Results：高血压是目前在68%的患者和糖尿病的37%，两者都发生在28%，都没有发生在23%。 非侵入性颈动脉研究确定动脉粥样硬化斑块为23%的可能栓塞源。 根据先前建立的标准，18%的人处于心源性栓塞的高风险中。 在高血压或糖尿病患者中，36%有颈动脉或心脏栓塞的风险。 那些没有高血压或糖尿病，32%有可能的颈动脉或心脏cause.Conclusions：高发病率的颈动脉和心脏疾病，在那些有和没有高血压或糖尿病提示在这个人群中的其他中风机制的重要性。 因此，腔隙性脑梗死患者应评估其他可治疗的卒中原因。
Background and Purpose: Lacunes are thought to occur in patients with hypertension or diabetes mellitus as a result of small-vessel disease. This study evaluated the importance of other stroke mechanisms in a population of patients with lacunar infarction.Methods: We evaluated 108 consecutive patients with a lacune in the lenticulostriate distribution for other stroke risk factors such as carotid and cardiac disease.Results: Hypertension was present in 68% of the patients and diabetes mellitus in 37%; both occurred in 28% and neither occurred in 23%. Noninvasive carotid studies identified atherosclerotic plaque as a possible embolic source in 23%. By previously established criteria, 18% were at high risk for cardioembolism. Of those with hypertension or diabetes mellitus, 36% were at risk for a carotid or cardiac embolus. Of those without hypertension or diabetes mellitus, 32% had a possible carotid or cardiac etiology.Conclusions: The high incidence of carotid and cardiac disease in those with and without hypertension or diabetes mellitus suggests the importance of other stroke mechanisms in this population. Patients with lacunar infarction should therefore be evaluated for other causes of stroke that may be treatable.