BEHAVIOR OF PLASMODIUM BERGHEI STRAINS ISOLATED FROM RELAPSED INFECTIONS OF WHITE MICE
BEHAVIOR OF PLASMODIUM BERGHEI STRAINS ISOLATED FROM RELAPSED INFECTIONS OF WHITE MICE
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DOI：
10.1111/j.1550-7408.1962.tb02591.x
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发表时间：
1962-01-01
期刊：
影响因子：
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通讯作者：
COX, HW
中科院分区：
文献类型：
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作者：
COX, HW
之前对复发性伯氏疟原虫感染小鼠的寄生虫进行的一项研究表明，复发性寄生虫的行为与其母株不同。已经进行了实验，比较了在两组条件下小鼠中复发和亲本寄生虫感染的行为。在一组实验中，测试了抗疟治疗后的行为，旨在导致慢性或潜伏感染状态。总之，在使用536只小鼠的六项不同实验中，针对其亲本菌株测试了8种复发菌株。观察到，与感染亲本菌株的小鼠相比，感染复发菌株的小鼠在治疗后具有统计学显著更高的死亡率。无论复发菌株先前如何治疗，或在实验中使用何种治疗，都观察到这种差异。在第二组实验中，在正常小鼠中比较复发和亲本寄生虫感染的行为。在使用356只小鼠的总共5个实验中，将5个复发菌株与它们的亲本菌株进行比较。观察到复发菌株感染的小鼠的平均存活时间显著大于亲本菌株感染的小鼠。目前尚不清楚复发和亲本寄生虫行为的这种明显差异是否与伯氏疟原虫感染复发的机制有关，或者仅仅是在免疫宿主中存活的寄生虫的特征。
A previous study of parasites from relapsed P. berghei infections of mice indicated that the behavior of the relapse parasites differed from that of their parent strain. Experiments have been performed comparing the behavior of relapse and parent parasite infections in mice under two sets of conditions. In one group of experiments the behavior after antimalarial treatments, designed to result in chronic or latent states of infection, was tested. In all, 8 relapse strains were tested against their parent strains in six different experiments which employed 536 mice. It was observed that the mice infected with the relapse strains had a statistically significant greater mortality after the treatments than did mice infected with parent strains. This difference was observed regardless of how the relapse strain had been previously treated, or of what treatment was used in the experiments. In a second group of experiments, the behavior of infections with relapse and parent parasites was compared in normal mice. Five relapse strains were compared to their parent strains in a total of 5 experiments using 356 mice. It was observed that the mean survival time of mice infected with relapse strains was significantly greater than that of mice infected with the parent strains. It is not known whether this apparent difference in the behavior of relapse and parent parasites is related to the mechanism for relapse of P. berghei infections, or is merely a characteristic of parasites that had survived in an immune host.