Levodopa-dyskinesia incidence by age of Parkinson's disease onset
Levodopa-dyskinesia incidence by age of Parkinson's disease onset
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DOI：
10.1002/mds.20360
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发表时间：
2005-03-01
影响因子：
8.6
通讯作者：
Ahlskog, JE
中科院分区：
文献类型：
--
作者：
Kumar, N;Van Gerpen, JA;Ahlskog, JE
我们在一个以人群为基础的队列中，根据帕金森病（PD）发病年龄评估了左旋多巴诱导的运动障碍的5年风险。罗切斯特流行病学项目的医疗记录链接系统被用来识别明尼苏达州奥姆斯特德县1976年至1990年期间发生PD的居民。在这项基于人群的研究中，5年运动障碍的发生率随着年龄的增长而下降。PD在70岁以后发病，发病率为16%。发病年龄在40 - 59岁之间，发病率较高，为50%。这些发生率数据可能高估了功能的重要性，因为计算了具有轻微或可逆性运动障碍的患者。(c)2004年，《运动障碍协会》。
We assessed the 5-year risk of levodopa-induced dyskinesias by age of Parkinson's disease (PD) onset in a population-based cohort. The medical records linkage system of the Rochester Epidemiology project was used to identify residents of Olmsted County, Minnesota, with incident PD for the period 1976 through 1990. In this population-based study, the 5-year dyskinesia incidence declined with age. With PD onset after 70 years of age, the incidence was 16%. With onset from 40 to 59 years of age, the incidence was higher at 50%. These incidence data may overestimate the functional importance, because patients with minimal or reversible dyskinesias were counted. (c) 2004 Movement Disorder Society.