The effect of different levels of dietary beta-carotene on DMBA-induced salivary gland tumors.
The effect of different levels of dietary beta-carotene on DMBA-induced salivary gland tumors.
复制标题
不同水平的膳食β-胡萝卜素对DMBA诱导的唾液腺肿瘤的影响。
DOI：
10.1080/01635588709513916
复制
发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Alam,SQ
中科院分区：
文献类型：
--
作者：
Alam,BS;Alam,SQ
Different levels of ß‐carotene (0, 5, 25, 125, and 250 mg/kg diet) were tested for their chemoprevention effects using 9,10‐dimethyl‐1,2‐benzanthracene‐induced salivary gland tumor model in rats. Tumor incidence and tumor weights were slightly lower in rats fed diets supplemented with 25 mg or more ß‐carotene/kg diet. Hepatic vitamin A and ß‐carotene levels were increased in a dose‐dependent fashion, reaching a plateau at 125 mg ß‐carotene/kg diet. In plasma, ß‐carotene concentrations were also increased with an increase in dietary ß‐carotene. Vitamin A levels in plasma were not affected. The normal salivary glands had higher concentrations of ß‐carotene than did the tumors. The results suggest that the decreases in tumor incidence and tumor weight may be related to the increase in plasma and tissue levels of ß‐carotene as a result of feeding high levels of ß‐carotene.
