Association between renin-angiotensin system antagonist use and mortality in heart failure with severe renal insufficiency: a prospective propensity score-matched cohort study
Association between renin-angiotensin system antagonist use and mortality in heart failure with severe renal insufficiency: a prospective propensity score-matched cohort study
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DOI：
10.1093/eurheartj/ehv268
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发表时间：
2015-09-07
影响因子：
39.3
通讯作者：
Lund, Lars H.
中科院分区：
文献类型：
--
作者：
Edner, Magnus;Benson, Lina;Lund, Lars H.
目的 对于射血分数 (EF) 降低的心力衰竭 (HF)，肾素-血管紧张素受体 (RAS) 拮抗剂可降低死亡率。然而，严重肾功能不全是试验中的排除标准。我们测试了 RAS 拮抗剂与严重肾功能不全的心衰患者死亡率降低相关的假设。方法和结果我们研究了 EF 221 μmol/L 或肌酐清除率 221 μmol/L 或肌酐清除率的患者
Aims In heart failure (HF) with reduced ejection fraction (EF), renin-angiotensin receptor (RAS) antagonists reduce mortality. However, severe renal insufficiency was an exclusion criterion in trials. We tested the hypothesis that RAS antagonists are associated with reduced mortality also in HF with severe renal insufficiency.Methods and results We studied patients with EF 221 mu mol/L or creatinine clearance 221 mu mol/L or creatinine clearance