High levels of vitamin D in relation to reduced risk of schizophrenia with elevated C-reactive protein.
High levels of vitamin D in relation to reduced risk of schizophrenia with elevated C-reactive protein.
复制标题
高水平的维生素 D 与降低 C 反应蛋白升高的精神分裂症风险有关。
DOI：
10.1016/j.psychres.2015.05.051
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Peng Zhu
中科院分区：
文献类型：
--
作者：
Daomin Zhu;Yong Liu;Aiguo Zhang;Zhaoxue Chu;Qing Wu;Hui Li;Jinfang Ge;Yi Dong;Peng Zhu
越来越多的证据表明维生素 D 在减轻炎症方面具有新的作用。本研究旨在检验以下假设：维生素 D 与精神分裂症患者的 C 反应蛋白 (CRP) 呈负相关，高水平的维生素 D 可能与 CRP 升高导致精神分裂症风险降低有关。这项横断面研究招募了 93 名精神分裂症患者和 93 名家庭匹配的对照者。使用商业试剂盒测量 CRP 和 25-羟基维生素 D [25(OH)D] 的血浆浓度。有关人口特征和临床数据的信息是通过访谈或医疗记录获得的。与对照组相比，患者的 CRP 和 25(OH)D 平均水平分别高出 43.3% 和低 26.7%。 25(OH)D 在患者中与 CRP 呈负相关，但在对照组中则不然。随着CRP四分位数的增加，患者比例显着增加，而随着25(OH)D四分位数的增加，患者比例显着下降。在高 CRP 个体中，与低 25(OH)D 参与者相比，高 25(OH)D 参与者患精神分裂症的比例显着较低（调整后 OR = 0.217，95% CI 0.063，0.751）。有证据表明，高水平的维生素 D 可能与 CRP 升高导致精神分裂症的风险降低有关。
There is growing evidence on the novel role of vitamin D in reducing inflammation. This study aimed to examine the hypothesis that vitamin D is inversely associated with C-reactive protein (CRP) in patients with schizophrenia, and high levels of vitamin D may be linked to reduced risk of schizophrenia with elevated CRP. Ninety-three patients with schizophrenia and 93 family-matched controls were recruited in this cross-sectional study. Plasma concentrations of CRP and 25-hydroxyvitamin D [25(OH)D] were measured using commercial kits. Information about demographic characteristics and clinic data were obtained by interviews or medical records. Mean levels of CRP and 25(OH)D were 43.3% higher and 26.7% lower for patients compared to controls, respectively. 25(OH)D were inversely associated with CRP in the patients, but not in the controls. The proportions of patients significantly increased with increasing quartiles of CRP, while significantly decreased with increasing quartiles of 25(OH)D. Among individuals with high CRP, participants with high 25(OH)D have significantly lower proportion (adjusted OR =0.217, 95% CI 0.063, 0.751) of schizophrenia compared to those with low 25(OH)D. The evidence suggested that high levels of vitamin D may be linked to reduced risk of schizophrenia with elevated CRP.