A pilot study linking reduced fronto-Striatal recruitment during reward processing to persistent bingeing following treatment for binge-eating disorder
A pilot study linking reduced fronto-Striatal recruitment during reward processing to persistent bingeing following treatment for binge-eating disorder
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DOI：
10.1002/eat.22204
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发表时间：
2014-05-01
影响因子：
5.5
通讯作者：
Potenza, Marc N.
中科院分区：
文献类型：
--
作者：
Balodis, Iris M.;Grilo, Carlos M.;Potenza, Marc N.
本研究的主要目的是检查奖励处理的神经生物学基础，可能与治疗结果暴饮暴食症（BED）. MethodBefore开始治疗，19肥胖的人寻求治疗BED进行了金钱奖励延迟任务功能磁共振成像（fMRI）。分析研究如何奖励处理相关的暴食状态4个月的treatment.ResultsTen个人继续报告暴食（BEpost-TX）治疗后，9个人没有（NBEpost-TX）的神经相关性。两组在体重指数方面没有差异。BEPost-tx组相对于NBEpost-tx组在奖励处理的预期阶段显示腹侧纹状体和额下回的募集减少，在奖励处理的结果阶段显示内侧前额叶皮层的活动减少。DiscussionThese results link brain reward circuitry to treatment outcome in BED，并表明奖励处理的特定脑区可能代表重要的治疗效果。床上的目标(c)2013 Wiley Periodicals，Inc. (Int J Eat Disord 2014; 47：376-384）
ObjectiveThe primary purpose of this study was to examine neurobiological underpinnings of reward processing that may relate to treatment outcome for binge-eating disorder (BED).MethodPrior to starting treatment, 19 obese persons seeking treatment for BED performed a monetary incentive delay task during functional magnetic resonance imaging (fMRI). Analyses examined how the neural correlates of reward processing related to binge-eating status after 4-months of treatment.ResultsTen individuals continued to report binge-eating (BEpost-tx) following treatment and 9 individuals did not (NBEpost-tx). The groups did not differ in body mass index. The BEpost-tx group relative to the NBEpost-tx group showed diminished recruitment of the ventral striatum and the inferior frontal gyrus during the anticipatory phase of reward processing and reduced activity in the medial prefrontal cortex during the outcome phase of reward processing.DiscussionThese results link brain reward circuitry to treatment outcome in BED and suggest that specific brain regions underlying reward processing may represent important therapeutic targets in BED. (c) 2013 Wiley Periodicals, Inc. (Int J Eat Disord 2014; 47:376-384)