Urea and protein carbamylation in ESRD: surrogate markers or partners in crime?
Urea and protein carbamylation in ESRD: surrogate markers or partners in crime?
复制标题
ESRD 中的尿素和蛋白质氨甲酰化：替代标记还是犯罪伙伴？
DOI：
10.1038/ki.2015.78
复制
发表时间：
2015
影响因子：
19.6
通讯作者：
Raj,DominicS
中科院分区：
文献类型：
--
作者：
Velasquez,ManuelT;Ramezani,Ali;Raj,DominicS
Protein carbamylation may result from chronic exposure to elevated levels of urea in patients with chronic kidney disease. Carbamylation could cause conformational changes in proteins resulting in alterations in binding sites and disturbances in cellular functions. Elevated levels of carbamylated protein have been shown to be associated with increased risk of death from cardiac causes in patients with end-stage renal disease. The precise mechanism by which carbamylated proteins mediate toxicity in uremia needs further investigation.
