Interethnic variability of warfarin maintenance requirement is explained by VKORC1 genotype in an Asian population
Interethnic variability of warfarin maintenance requirement is explained by VKORC1 genotype in an Asian population
复制标题
DOI：
10.1016/j.clpt.2005.11.006
复制
发表时间：
2006-03-01
影响因子：
6.7
通讯作者：
Goh, BC
中科院分区：
文献类型：
--
作者：
Lee, SC;Ng, SS;Goh, BC
背景资料。据报道，中国人和马来人比印度人需要更少的维持性华法林，而细胞色素P450(CYP)2C9变种无法解释这一点。结果：华法林的平均体重标准化剂量在中国人和马来人低于印度人(分别为0.058+/-0.025 mg/kg、0.059+/0.023 mg/kg和0.089+/-0.036 mg/kg)。P<；.001用于比较华人和马来人与印度人之间的关系)。CYP2C9*2和VKORC1编码区变异很少见(
Background. Chinese and Malay subjects have been reported to require less maintenance warfarin than Indians that could not be accounted for by cytochrome P450 (CYP) 2C9 variants. Vitamin K epoxide reductase complex 1 (VKORC1) is the target enzyme of warfarin, and VKORC1 intronic variants and haplotypes have recently been shown to influence VKORC1 activity and warfarin requirements.Methods: We sequenced the coding regions of CYP2C9 and VKORC1 and inferred VKORC1 haplotype from 10 intronic variants in 147 Chinese, 85 Malay, and 43 Indian patients receiving maintenance warfarin.Results: The mean weight-normalized warfarin dose was lower for Chinese and Malays than for Indians (0.058 +/- 0.025 mg/kg, 0.059 +/- 0.023 mg/kg, and 0.089 +/- 0.036 mg/kg, respectively; P < .001 for comparisons between Chinese and Malays with Indians). CYP2C9*2 and VKORC1 coding region variants were rare (