Obesity enhanced respiratory health effects of ambient air pollution in Chinese children: the Seven Northeastern Cities study
Obesity enhanced respiratory health effects of ambient air pollution in Chinese children: the Seven Northeastern Cities study
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DOI：
10.1038/ijo.2012.125
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发表时间：
2013-01-01
影响因子：
4.9
通讯作者：
Trevathan, E.
中科院分区：
文献类型：
--
作者：
Dong, G. H.;Qian, Z.;Trevathan, E.
目的：实验数据表明，肥胖增强了环境空气污染物对哮喘恶化的影响；然而，缺乏流行病学证据支持。本研究的目的是评估肥胖是否改变了环境空气污染与儿童呼吸道症状和哮喘的关系。方法：在东北地区，从7个城市的25个区中抽取30056名2~14岁的儿童。孩子的父母完成了问卷，这些问卷描述了孩子的呼吸道症状和病史，以及相关的风险因素。超重和肥胖是用年龄和性别相关的身体质量指数(BMI，kg m(-2))计算的，BMI分别大于第85和第95个百分位数定义超重和肥胖。空气动力学直径颗粒物的年均环境暴露量
OBJECTIVE: Experimental data suggest that obesity enhances the effects of ambient air pollutants on exacerbation of asthma; however, there is little supporting epidemiological evidence. The aim of present study is to evaluate whether obesity modifies the association between ambient air pollution and respiratory symptoms and asthma in children.METHODS: In Northeast China, 30 056 children aged 2-14 years were selected from 25 districts of seven cities. Parents of the children completed questionnaires that characterized the children's histories of respiratory symptoms and illness, and associated risk factors. Overweight and obesity were calculated with an age and sex-specific body mass index (BMI, kg m(-2)), with BMIs of greater than the 85th and 95th percentiles defining overweight and obesity, respectively. Average annual ambient exposure to particulate matter with an aerodynamic diameter