The human TRIP6 gene encodes a LIM domain protein and maps to chromosome 7q22, a region associated with tumorigenesis
The human TRIP6 gene encodes a LIM domain protein and maps to chromosome 7q22, a region associated with tumorigenesis
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DOI：
10.1006/geno.1998.5248
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发表时间：
1998-04-15
期刊：
影响因子：
4.4
通讯作者：
Beckerle, MC
中科院分区：
文献类型：
--
作者：
Yi, JS;Beckerle, MC
甲状腺受体相互作用蛋白-6（TRIP 6）首先在酵母双杂交筛选中被鉴定为甲状腺激素受体的配体依赖性结合伴侣。在初始筛选中分离的部分TRIP 6 cDNA克隆编码两个拷贝的LIM结构域。LIM结构域是介导蛋白质-蛋白质相互作用的双锌指结构。TRIP 6蛋白显示富含脯氨酸的N-末端区域连接到三个串联排列的C末端LIM结构域。TRIP 6的整体分子结构和序列将其与粘附斑块蛋白、zyxin和脂肪瘤优选伴侣（LPP）置于同一家族中。Zyxin和LPP分别涉及细胞信号传导和肿瘤发生。通过放射杂交定位，将人TRIP 6基因定位于染色体7 q22的一个区段，该区段通常在恶性骨髓疾病和子宫平滑肌瘤中缺失。(C)北京：科学出版社.
The thyroid receptor interacting protein-6 (TRIP6) was first identified as a ligand-dependent binding partner for the thyroid hormone receptor in a yeast two-hybrid screen. A partial TRIP6 cDNA clone that was isolated in the initial screen encodes two copies of the LIM domain. The LIM domain is a double zinc-finger structure that mediates protein-protein interactions, Here we report the complete amino acid sequence of human TRIP6. The TRIP6 protein displays a proline-rich N-terminal region linked to three tandemly arrayed C terminal LIM domains. The global molecular architecture and sequence of TRIP6 place it in the same family as the adhesion plaque protein, zyxin, and the lipoma preferred partner (LPP). Zyxin and LPP are implicated in cellular signaling and tumorigenesis, respectively. By radiation hybrid mapping, the human TRIP6 gene was assigned to a segment of chromosome 7q22 that is commonly deleted in malignant myeloid diseases and uterine leiomyoma. (C) 1998 Academic Press.