Phagocyte transport as mechanism for enhanced therapeutic activity of liposomal amphotericin B.
Phagocyte transport as mechanism for enhanced therapeutic activity of liposomal amphotericin B.
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DOI：
10.1159/000239202
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发表时间：
1994-07
期刊：
影响因子：
3.3
通讯作者：
Reeta Mehta;Teresa Mcqueen;A. Keyhani;G. Lopez-Berestein
中科院分区：
文献类型：
--
作者：
Reeta Mehta;Teresa Mcqueen;A. Keyhani;G. Lopez-Berestein
Liposomal amphotericin B (L-AmB) is emerging as one of the most attractive new antifungal agents. We have attempted to show that phagocytic cells circulating in blood play an important role in transport and accumulation of L-AmB at inflammatory sites in vivo. Free AmB or L-AmB was injected intravenously to mice, and the amount of AmB in peritoneal exudate cells was quantitated by high-performance liquid chromatography. Higher levels of AmB were detected in a higher number of mice injected with L-AmB. The presence of L-AmB in inflammatory peritoneal cells after intravenous administration of fluorescence-labeled L-AmB also suggested that macrophages play an important role in the transport of intravenously administered L-AmB to inflammatory sites.
