Chorion releases a factor that inhibits oxytocin-stimulated myometrial contractility in the pregnant guinea pig.
Chorion releases a factor that inhibits oxytocin-stimulated myometrial contractility in the pregnant guinea pig.
复制标题
绒毛膜释放一种因子，抑制怀孕豚鼠催产素刺激的子宫肌层收缩力。
DOI：
10.1093/humrep/16.4.638
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Weiner,CP
中科院分区：
文献类型：
--
作者：
Carvajal,JA;Buhimschi,IA;Thompson,LP;Aguan,K;Weiner,CP
据推测，绒毛膜释放一种维持妊娠期间子宫静止所必需的物质。在妊娠结束时，这种物质的释放减少对于正常的子宫肌层激活是必要的。通过证明绒毛膜在体外抑制催产素刺激的子宫肌层收缩的能力来验证这一假设。组织从早产或近足月妊娠的定时妊娠Duncan-Hartley豚鼠中获得。将子宫肌条置于器官浴槽中进行等长张力测量和催产素（10- 8 mol/l）刺激的收缩。将来自绒毛膜的胎膜或条件培养基直接加入器官浴中。近期绒毛膜和绒毛膜条件培养基减少催产素刺激的收缩活动分别为39%和49%。早产儿和近期羊水都没有降低催产素刺激的子宫肌层收缩活动。早产绒毛膜组的舒张作用大于近足月绒毛膜组（分别为催产素基础水平的23%和41%，P< 0.05）。此外，绒毛膜诱导的松弛是独立的子宫肌层的胎龄。人绒毛膜从一个任期，而不是在劳动妇女也抑制催产素刺激豚鼠子宫肌层收缩。结论是绒毛膜释放一种或多种物质，降低催产素刺激的子宫肌层收缩力，并可能参与妊娠期间子宫静止的维持。
It was postulated that chorion releases a substance necessary for the maintenance of uterine quiescence during pregnancy. A decrease in the release of this substance at the end of the pregnancy would be necessary for normal myometrial activation. This hypothesis was tested by demonstrating the ability of chorion to inhibit oxytocin-stimulated myometrial contractilityin vitro. Tissues were obtained from timed pregnant Duncan-Hartley guinea pigs either at pre-term or near-term gestation. Myometrial strips were placed in organ baths for isometric tension measurement and contractions stimulated by oxytocin (10–8mol/l). Fetal membranes or conditioned medium from chorion were added directly to the organ bath. Near-term chorion and chorion conditioned-medium decreased oxytocin-stimulated contractile activity to 39% and 49% respectively. Neither pre-term nor near-term amnion reduced oxytocin-stimulated myometrial contractile activity. Relaxation induced by pre-term chorion was greater than near-term chorion (23% and 41% of the oxytocin-induced basal level respectively;P< 0.05). Further, chorion-induced relaxation was independent of the gestational age of the myometrium. Human chorion from a term, not-in-labour woman also inhibited oxytocin-stimulated guinea pig myometrial contractility. It was concluded that the chorion releases a substance or substances that reduce oxytocin-stimulated myometrial contractility and may be involved in the maintenance of uterine quiescence during pregnancy.