Chemical Constituents And Antibacterial Activities Of The Stem Bark Extracts Of Ricinodendron Heudelotii (Euphorbiaceae).
Chemical Constituents And Antibacterial Activities Of The Stem Bark Extracts Of Ricinodendron Heudelotii (Euphorbiaceae).
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发表时间：
2005-05
影响因子：
0.5
通讯作者：
J. Momeni;R. Djoulde;M. Akam;S. Kimbu
中科院分区：
文献类型：
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作者：
J. Momeni;R. Djoulde;M. Akam;S. Kimbu
对大戟科植物蓖麻（Ricinodendron heudelotii（Baill）Pierre ex Pax）的茎皮进行了研究，经正己烷和甲醇/二氯甲烷提取物的硅胶柱层析，得到紫胶桐酸1和labda-8（17），13-二烯-3I ²，15-二醇2，它们是首次与E-阿魏酸二十八烷基酯3一起沿着分离得到的。用光谱学方法进行了结构鉴定。使用纸片扩散法评价的正己烷和MeOH/CH 2Cl 2浸提液的抗微生物活性表明，这些浸提液对某些供试微生物的活性高于所用的某些市售抗生素。对于所测试的八种微生物，正己烷提取物的最小抑菌浓度（MIC）为4.6 ±1.2至22 ±4 mg/ml，MeOH/CH 2Cl 2提取物的最小抑菌浓度为5. ±21.2至20 ±1.5 mg/ml。发现粪链球菌是最敏感的微生物，正己烷浸提液的MIC为4.6 mg/ml。这些抗菌特性可能部分解释了这种植物在传统医学中的用途。
Studies were carried out on the stem bark of Ricinodendron heudelotii (Baill) Pierre ex Pax (Euphorbiaceae).The phytochemical examination of the n-hexane and methanol/methylene chloride extracts by silica gel chromatography afforded aleuritolic acid 1 and labda-8(17),13-dien- 3I²,15-diol 2, which were isolated for the first time along with E-ferulic acid octacosylate 3. The structures were elucidated using spectroscopic methods. The antimicrobial activity of the n-hexane and MeOH/CH2Cl2 extracts evaluated using disc diffusion method showed that these extracts were more active against some of the microorganisms tested than some commercially available antibiotics used. For the eight microorganisms tested, the minimal inhibitory concentration (MIC) obtained varied from 4.6±1.2 to 22±4 mg/ml for the n-hexane extract and from 5.±21.2 to 20±1.5 mg/ml for the MeOH/CH2Cl2 extract. Streptococcus faecalis was found being the most susceptible organism with a MIC of 4.6 mg/ml for the n-hexane extract. These antimicrobial properties probably explain partly, the use of this plant in traditional medicine.