Pre- and postsynaptic actions of adenosine in the in vitro rat hippocampus.
Pre- and postsynaptic actions of adenosine in the in vitro rat hippocampus.
复制标题
腺苷在体外大鼠海马中的突触前和突触后作用。
DOI：
10.1016/0006-8993(87)90441-0
复制
发表时间：
1987
期刊：
影响因子：
2.9
通讯作者：
Dunwiddie,TV
中科院分区：
文献类型：
--
作者：
Proctor,WR;Dunwiddie,TV
在体外大鼠海马区研究了腺苷抑制兴奋性突触传递的机制。通过比较超融合腺苷对EPSP幅度和局部应用谷氨酸的去极化反应的影响，评价腺苷对CA1锥体神经元的直接作用(超极化、电导增加)的相对贡献。在32例患者中，有30例腺苷对突触EPSP的抑制程度大于谷氨酸反应，其作用与谷氨酸的作用部位无关(躯体细胞与树突细胞)。因此，腺苷的突触后效应，包括可能的树突电导，在体细胞记录中是无法检测到的，只能部分解释用腺苷观察到的突触电位的抑制。
The mechanisms underlying the depressant effect of adenosine on excitatory synaptic transmission were studied in rat hippocampus in vitro. The relative contribution of direct effects of adenosine upon CA1pyramidal neurons (hyperpolarization, increased conductance) was evaluated by comparing the effects of superfused adenosine on EPSP amplitude, and on depolarizing responses to local application of glutamate. Adenosine depressed synaptic EPSPs to a greater extent than glutamate responses in 30 out of 32 cases, and its effects were independent of the site of glutamate application (somatic vs dendritic). Thus, the postsynaptic effects of adenosine, including a possible dendritic conductance that would be undetectable with somatic recordings, can only partially account for the depression of synaptic potentials observed with adenosine.