Smaller corpus callosum subregions containing motor fibers in schizophrenia
Smaller corpus callosum subregions containing motor fibers in schizophrenia
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DOI：
10.1016/j.schres.2004.08.023
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发表时间：
2005-02-01
影响因子：
4.5
通讯作者：
Honer, WG
中科院分区：
文献类型：
--
作者：
Goghari, VM;Lang, DJ;Honer, WG
神经心理学和神经生理学研究为精神分裂症患者大脑半球间通讯异常提供了证据。本研究调查了27例精神分裂症患者和31例健康对照者。从正中矢状SPGR切片获得胼胝体的全局和区域测量值。在8个功能特异性亚区的MANCOVA中发现了诊断[Wilks' Lambda F（8，46）=2.45，p=0.03]和年龄相互作用诊断[Wilks' Lambda F（8，46）=2.58，p=0.02]的总体效应。具体而言，慢性精神分裂症与较小的吻侧体[降低6.9%，F（1，53）=9.70，p=0.003]和前中体[降低9.7%，F（1，53）=4.89，p=0.03]亚区相关。精神分裂症患者相关皮层区域的功能异常也有报道。这些新的发现表明，胼胝体的结构异常存在于精神分裂症，可能是运动特异性亚区比其他受影响。胼胝体的结构差异可能是精神分裂症患者大脑半球间功能性连接障碍的基础。(C)2004 Elsevier B.V.保留所有权利。
Neuropsychological and neurophysiological studies provide evidence for abnormal interhemispheric communication in schizophrenia. These abnormalities may have a substrate in structural irregularities of the corpus callosum.This study investigated schizophrenia patients (n=27) and healthy comparison subjects (n=31). Global and regional measurements of the corpus callosum were acquired from one midsagittal SPGR slice. Eight subregions were approximately matched to fiber pathways from cortical regions.Overall effects of diagnosis [Wilks' Lambda F(8,46)=2.45, p=0.03] and diagnosis by age interaction [Wilks' Lambda F(8,46)=2.58, p=0.02] were found in a MANCOVA of the eight functionally specific subregions. Specifically, chronic schizophrenia was associated with a smaller rostral body [lower by 6.9%, F(1,53)=9.70, p=0.003] and anterior midbody [lower by 9.7%, F(1,53)=4.89, p=0.03] subregions.The rostral body and anterior midbody subregions of the corpus callosum primarily have premotor, supplementary motor, and motor cortical fibers transversing through them. Functional abnormalities of the associated cortical regions are reported in schizophrenia. These novel findings suggest that structural abnormalities of the corpus callosum exist in schizophrenia, with perhaps the motor-specific subregions affected more than others. Structural differences in the corpus callosum may be a substrate for interhemispheric functional dysconnectivity in schizophrenia. (C) 2004 Elsevier B.V. All rights reserved.