Mechanical properties of completely autologous human tissue engineered blood vessels compared to human saphenous vein and mammary artery.
Mechanical properties of completely autologous human tissue engineered blood vessels compared to human saphenous vein and mammary artery.
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DOI：
10.1016/j.biomaterials.2008.11.011
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发表时间：
2009-03
期刊：
影响因子：
14
通讯作者：
L'Heureux, Nicolas
中科院分区：
文献类型：
--
作者：
Konig, Gerhardt;McAllister, Todd N.;Dusserre, Nathalie;Garrido, Sergio A.;Iyican, Corey;Marini, Alicia;Fiorillo, Alex;Avila, Hernan;Wystrychowski, Wojciech;Zagalski, Krzysztof;Maruszewski, Marcin;Jones, Alyce Linthurst;Cierpka, Lech;de la Fuente, Luis M.;L'Heureux, Nicolas
关键词：
我们先前已经报道了我们的小直径组织工程血管（TEBV）的初步临床可行性。在这里，我们提出了在体外结果的机械性能的TEBV的前25名患者参加了动静脉（AV）分流安全性试验，并比较这些属性与风险匹配的人体静脉和动脉。TEBV平均爆破压（3，490 +/− 892 mmHg，n=230）高于自体隐静脉（SV）（1，599 +/− 877 mmHg，n=7），与自体乳内动脉（IMA）（3，196 +/− 1，264 mmHg，n=16）无显著差异。TEBV的缝线固位强度（152 +/− 50 gmf）与IMA（138 +/− 50 gmf）也没有显著差异。植入前TEBV的顺应性（3.4 +/− 1.6%/100 mmHg）低于IMA（11.5 +/− 3.9%/100 mmHg）。植入后6个月，TEBV顺应性（8.8 +/− 4.2%/100 mmHg，n=5）增加至与IMA相当的值，并且没有扩张或动脉瘤形成的证据。由于临床时间点超过21个月，作为无干预的A-V分流，此处报告的机械试验和后续批次放行标准似乎是组织工程血管临床使用的适当最低标准。
We have previously reported initial clinical feasibility with our small diameter tissue engineered blood vessel (TEBV). Here we present in vitro results of the mechanical properties of the TEBVs of the first 25 patients enrolled in an arterio-venous (A-V) shunt safety trial, and compare these properties with those of risk-matched human vein and artery. TEBV average burst pressures (3,490 +/− 892 mmHg, n=230) were higher than native saphenous vein (SV) (1,599 +/− 877 mmHg, n=7), and not significantly different than native internal mammary artery (IMA) (3,196 +/− 1,264 mmHg, n=16). Suture retention strength for the TEBVs (152 +/− 50 gmf) was also not significantly different than IMA (138 +/− 50 gmf). Compliance for the TEBVs prior to implantation (3.4 +/− 1.6 %/100 mmHg) was lower than IMA (11.5 +/− 3.9 %/100 mmHg). By 6 months post-implant, the TEBV compliance (8.8 +/− 4.2 %/100 mmHg, n=5) had increased to values comparable to IMA, and showed no evidence of dilation or aneurysm formation. With clinical time points beyond 21 months as an A-V shunt without intervention, the mechanical tests and subsequent lot release criteria reported here would seem appropriate minimum standards for clinical use of tissue engineered vessels.
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