Clinical and Computed Tomography (CT) Characteristics of Pulmonary Nodules Caused by Cryptococcal Infection.
Clinical and Computed Tomography (CT) Characteristics of Pulmonary Nodules Caused by Cryptococcal Infection.
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DOI：
10.2147/idr.s330159
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发表时间：
2021
影响因子：
3.9
通讯作者：
Chu ZG
中科院分区：
文献类型：
--
作者：
Chen F;Liu YB;Fu BJ;Lv FJ;Chu ZG
探讨隐球菌感染所致肺结节的临床及CT特征，为减少误诊提供依据。回顾性分析2013年1月至2020年12月共47例以结节为表现的确诊肺隐球菌病（PC）患者。对单发和多发结节的临床及CT资料进行分析比较，重点探讨单发结节的特点。47例患者中，单发结节25例（53.2%），多发结节22例（46.8%），临床特征相似。单发结节的直径小于多发结节中最大结节的直径（P = 0.000）。与多发结节相比，胸膜下单发结节较少（P = 0.031），有空腔或空泡（P = 0.049）。孤立性结节22例（88.0%），实性结节3例（12.0%）；实性孤立性结节18例（81.8%）表现为支气管气征或空泡、卫星征和晕征之一。25例孤立性结节患者中有23例（92.0%）随访CT资料，大多数结节大小和/或密度没有变化（12.52.1%）或增加（8.34.8%），但只有少数结节在接受或不接受抗炎治疗时缩小（3.13.0%）。PC所致单发结节与多发结节的临床特征相似。单发结节较小，更分散，但坏死程度低于多发结节。孤立性结节伴支气管气征或空泡、卫星病变或晕征，应考虑PC作为鉴别诊断之一。
To investigate the clinical and computed tomography (CT) characteristics of pulmonary nodules caused by cryptococcal infection and gain a greater insight and understanding that will reduce misdiagnosis. A total of 47 patients with confirmed pulmonary cryptococcosis (PC) manifested as nodules were retrospectively enrolled from January 2013 to December 2020. The clinical and CT data of patients with single and multiple nodules were analyzed and compared with emphasis on exploring the characteristics of the solitary ones. Among the 47 patients, single and multiple nodules were detected in 25 (53.2%) and 22 (46.8%) patients, respectively, with similar clinical characteristics. The diameter of solitary nodules was smaller than that of the largest ones of the multiple nodules (P = 0.000). Compared with multiple nodules, less solitary nodules were located in the subpleural zone (P = 0.031) and had a cavity or vacuole (P = 0.049). Regarding the solitary nodules, 22 (88.0%) and 3 (12.0%) were solid and subsolid, respectively. Eighteen (81.8%) solid solitary nodules exhibited either one of air bronchogram or vacuole, satellite lesions, and halo sign. Twenty-three (92.0%) of 25 patients with solitary nodules had follow-up CT data, and most of them had no changes (12, 52.1%) or increased in size and/or density (8, 34.8%), but only a few (3, 13.0%) decreased with or without anti-inflammatory therapy. The clinical characteristics of patients with solitary and multiple nodules caused by PC are similar. The solitary nodules are smaller, more scattered, but less necrotic than multiple ones. For solitary nodules with air bronchogram or vacuole, satellite lesions, or halo sign, PC should be considered as one of the differential diagnosis.
DOI：
10.12659/ajcr.905905
发表时间：
2017-10-26
期刊：
The American journal of case reports
影响因子：
--
作者：
Li A;Li Q;Guo C;Zhang Y
通讯作者：
Zhang Y