Toward an artificial aldolase
Toward an artificial aldolase
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DOI：
10.1021/ol702901z
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发表时间：
2008-01-17
期刊：
影响因子：
5.2
通讯作者：
Pericas, Miquel A.
中科院分区：
文献类型：
--
作者：
Font, Daniel;Sayalero, Sonia;Pericas, Miquel A.
一种新的功能聚合物，其中Pro通过1，2，3-三氮唑连接物与聚苯乙烯键合，描述了以人工醛缩酶为靶标的特征。尽管聚合物骨架具有疏水性，但树脂在水中会膨胀，形成水中微环境。这一性质是由于形成了连接脯氨酸和1，2，3-三氮唑片段的氢键网络，在水中对直接羟醛缩合反应具有非常高的催化活性和对映体选择性。
A new functional polymer where proline is bonded to polystyrene through a 1,2,3-triazole linker depicts characteristics targeted for an artificial aldolase. In spite of the hydrophobicity of the polymer backbone, the resin swells in water with building of an aqueous microenvironment. This property, arising from the formation of a hydrogen-bond network connecting the proline and 1,2,3-triazole fragments, is translated into a very high catalytic activity and enantioselectivity toward direct aldol reactions in water.