Review of culprit drugs associated with patients admitted to the burn unit with the diagnosis of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Syndrome.
Review of culprit drugs associated with patients admitted to the burn unit with the diagnosis of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Syndrome.
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DOI：
10.1016/j.burns.2021.08.009
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发表时间：
2022-11
期刊：
影响因子：
2.7
通讯作者：
Bouchard, Charles
中科院分区：
文献类型：
--
作者：
De Bustros, Paul;Baldea, Anthony;Sanford, Arthur;Joyce, Cara;Adams, William;Bouchard, Charles
史蒂文斯-约翰逊综合征(SJS)和中毒性表皮坏死松解综合征(TENS)是一种严重的、具有潜在致命性的药物不良反应，其特征是皮肤、粘膜和眼表的急性炎症，通常发生在罪犯服药后数周内。这项研究的目的是报告洛约拉大学医学中心(LUMC)烧伤病房入院的SJS谱诊断和相关罪魁祸首药物的回顾性趋势分析，LUMC是芝加哥地区SJS病谱患者的主要转诊中心。对2000年至2019年收治的163例SJS/TENS患者的电子病历进行了回顾分析。除了公认的表皮坏死松解(ALDEN)的药物因果关系算法外，临床数据还使我们能够在131个病例中识别出最可能的罪魁祸首药物。从2000年到2019年，最常见的频谱分类是TENS(48.1%)，其次是SJS(33.6%)和SJS-TEN重叠综合征(18.3%)。30%的病例发现抗惊厥药物是最可能的罪魁祸首，其次是甲氧苄氨嘧啶-磺胺甲恶唑，占19%。在11%的病例中，β-内酰胺类药物是最可能的罪魁祸首，而在8.4%的病例中，非甾体抗炎药和别嘌醇分别是最可能的罪魁祸首/药物。这是美国最大的单中心系列SJS/TENS病例之一。进一步研究按区域分列的罪犯药物分配情况以及持续监测趋势至关重要，以便为处方做法提供建议。
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis Syndrome (TENS) are severe and potentially lethal adverse drug reactions characterized by acute inflammation of the skin, mucous membranes, and ocular surface that typically occurs within weeks of a culprit drug ingestion. The purpose of this study is to report a retrospective trend analysis of SJS spectrum diagnoses and associated culprit drugs in patients admitted to the Loyola University Medical Center (LUMC) Burn Unit, the major referral center in the Chicagoland region for patients with SJS disease spectrum. The electronic medical records (EMR) of 163 patients with a diagnosis of SJS/TENS admitted to the LUMC Burn Unit from 2000 to 2019 were reviewed. Clinical data in addition to the well-established algorithm of drug causality for epidermal necrolysis (ALDEN) allowed us to identify the single most probable culprit drug in 131 cases. From 2000 to 2019, the most common spectrum classification was TENS (48.1%), followed by SJS (33.6%) and SJS-TEN Overlap Syndrome (18.3%). Anticonvulsants were found to be the most probable culprit class in 30% of cases followed by Trimethoprim-Sulfamethoxazole in 19% of cases. Beta-lactams were the most probable culprit class in 11% of cases while NSAIDs and allopurinol were each the most probable culprit class/drug in 8.4% of cases. This is one of the largest single center series of SJS/TENS cases in the United States. Further study into culprit drug distribution by region as well as continuous monitoring of trends is crucial in order to advise prescribing practices.
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DOI：
10.1073/pnas.0409500102
发表时间：
2005-03-15
影响因子：
11.1
作者：
Hung, SL;Chung, WH;Chen, YT
通讯作者：
Chen, YT
DOI：
10.1136/bmj.h4848
发表时间：
2015-09-23
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Ko TM;Tsai CY;Chen SY;Chen KS;Yu KH;Chu CS;Huang CM;Wang CR;Weng CT;Yu CL;Hsieh SC;Tsai JC;Lai WT;Tsai WC;Yin GD;Ou TT;Cheng KH;Yen JH;Liou TL;Lin TH;Chen DY;Hsiao PJ;Weng MY;Chen YM;Chen CH;Liu MF;Yen HW;Lee JJ;Kuo MC;Wu CC;Hung SY;Luo SF;Yang YH;Chuang HP;Chou YC;Liao HT;Wang CW;Huang CL;Chang CS;Lee MT;Chen P;Wong CS;Chen CH;Wu JY;Chen YT;Shen CY;Taiwan Allopurinol-SCAR Consortium
通讯作者：
Taiwan Allopurinol-SCAR Consortium
影响因子：
6.5
作者：
Hsu, Derek Y.;Brieva, Joaquin;Silverberg, Jonathan I.
通讯作者：
Silverberg, Jonathan I.
影响因子：
5.6
作者：
Fang, Hua;Xu, Xiequn;Moreno, Tanya A.
通讯作者：
Moreno, Tanya A.
影响因子：
5.9
作者：
Miliszewski, Monica A.;Kirchhof, Mark G.;Dutz, Jan P.
通讯作者：
Dutz, Jan P.