The epidemic of type 1 diabetes: what is it telling us?
The epidemic of type 1 diabetes: what is it telling us?
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DOI：
10.1097/med.0b013e32834872ce
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发表时间：
2011-08-01
影响因子：
3.2
通讯作者：
Rewers, Marian
中科院分区：
文献类型：
--
作者：
Forlenza, Gregory P.;Rewers, Marian
综述目的1型糖尿病（T1D）是一种自身免疫性疾病，影响着全世界数百万人。儿童T1D的发病率在全球范围内以无法仅用遗传学解释的速度增加。本文综述了近年来有关T1D流行的可能原因的研究。这些理论包括感染，幼儿饮食，维生素D暴露，环境污染物，身高增长速度增加，肥胖和胰岛素抵抗在T1D风险中的作用。在过去的一年中，证据已经加强了幼儿感染，膳食蛋白质和胰岛素抵抗作为T1D的危险因素，但不是维生素D暴露或环境污染物。
Purpose of reviewType 1 diabetes (T1D) is an autoimmune disorder which affects millions around the world. The incidence of T1D in children is increasing worldwide at a rate that cannot be explained by genetics alone. This review explores the recent research regarding possible causes of this epidemic.Recent findingsInvestigation into T1D epidemiology has recently focused on several hypotheses. These theories include the role of infections, early childhood diet, vitamin D exposure, environmental pollutants, increased height velocity, obesity, and insulin resistance in the risk for T1D. Over the past year, the evidence has strengthened for early childhood infections, dietary proteins, and insulin resistance as risk factors for T1D, but not for vitamin D exposure or environmental pollutants.SummaryInvestigation into the source of the current epidemic of T1D has shed light on several possible causes, but has not provided definitive answers, yet.