MODULATION OF THE TIME COURSE OF FAST EPSCS AND GLUTAMATE CHANNEL KINETICS BY ANIRACETAM
MODULATION OF THE TIME COURSE OF FAST EPSCS AND GLUTAMATE CHANNEL KINETICS BY ANIRACETAM
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DOI：
10.1126/science.1681589
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发表时间：
1991-10-11
期刊：
影响因子：
56.9
通讯作者：
LYNCH, G
中科院分区：
文献类型：
--
作者：
TANG, CM;SHI, QY;LYNCH, G
一般认为谷氨酸是哺乳动物中枢神经系统（CNS）中大多数兴奋性突触的神经递质。 谷氨酸的突触释放可以触发快速和缓慢的兴奋性突触后电流（EPSC）。 慢EPSC由N-甲基-D-天冬氨酸（NMDA）受体通道介导，而快EPSC由非NMDA受体通道介导。 促智剂阿尼西坦选择性地和可逆地减慢非NMDA通道的脱敏动力学，并延长其单通道开放时间。 阿尼西坦还以反映其对非NMDA通道动力学的作用的方式调节快速EPSC的动力学。 这些结果支持的假设，即非NMDA谷氨酸通道，而不是神经递质清除率的性质是哺乳动物中枢神经系统中的快速EPSC的动力学的主要决定因素。
It is generally accepted that glutamate serves as the neurotransmitter at most excitatory synapses in the mammalian central nervous system (CNS). Synaptic release of glutamate may trigger a fast and a slow excitatory postsynaptic current (EPSC). The slow EPSC is mediated by N-methyl-D-aspartate (NMDA) receptor channels, whereas the fast EPSC is mediated by non-NMDA receptor channels. The nootropic agent aniracetam selectively and reversibly slows the desensitization kinetics of non-NMDA channels and lengthens their single-channel open times. Aniracetam also modulates the kinetics of the fast EPSC in a manner that mirrors its action on the kinetics of the non-NMDA channels. These results support the hypothesis that the properties of the non-NMDA glutamate channels rather than the rate of neurotransmitter clearance are the primary determinants of the kinetics of the fast EPSC in the mammalian CNS.