Green tea and coffee intake and risk of pancreatic cancer in a large-scale, population-based cohort study in Japan (JPHC study)
Green tea and coffee intake and risk of pancreatic cancer in a large-scale, population-based cohort study in Japan (JPHC study)
复制标题
DOI：
10.1097/cej.0b013e32809b4d30
复制
发表时间：
2007-12-01
影响因子：
2.4
通讯作者：
Tsugane, Shoichiro
中科院分区：
文献类型：
--
作者：
Luo, Juhua;Inoue, Manami;Tsugane, Shoichiro
胰腺癌是人类最具侵袭性和治疗难治性的恶性肿瘤之一。降低胰腺癌死亡率的最有效方法可能是一级预防。虽然实验室研究已经证明绿色茶具有抗癌活性，但流行病学研究的结果未能显示出一致的癌症预防效果。此外，人们一直担心咖啡会增加胰腺癌的风险，尽管最近的流行病学研究表明咖啡和风险之间没有整体联系。在这里，我们在日本进行了一项大型人群队列研究（JPHC研究），研究了饮用绿色茶或咖啡与胰腺癌风险之间的关系。到2003年底，总共对102137名参与者进行了平均11年的跟踪调查。在116945人年的随访中，共发现233例胰腺癌事件。总体而言，胰腺癌的风险与我们人群中的绿色茶或咖啡摄入量无关，尽管与不喝或很少喝咖啡的人相比，每天至少喝三杯咖啡的男性的风险明显降低。总之，我们的研究结果支持这样一种观点，即绿色茶或咖啡的消费对胰腺癌的风险没有实质性的影响。
Pancreatic cancer is one of the most aggressive and treatment-refractory malignancies in humans. The most effective means of reducing pancreatic cancer mortality may be primary prevention. Although laboratory studies have demonstrated that green tea possesses anticancer activities, results from epidemiological studies have failed to show a consistent cancer-preventive effect. In addition, there is a lingering concern that coffee mighty increase the risk of pancreatic cancer although the most recent epidemiological studies showed no overall association between coffee and risk. Here, we examined the association between the drinking of green tea or coffee and the risk of pancreatic cancer in a large population-based cohort study in Japan (JPHC study). In total, 102137 participants were followed for an average of 11 years through to the end of 2003. A total of 233 incident cases of pancreatic cancer were identified among 1 16 945 person-years of follow-up. Overall, the risk of pancreatic cancer was not associated with either green tea or coffee intake in our population, although a reduced risk was apparent among men who drank at least three cups of coffee per day compared with those who did not drink any or only rarely drank coffee. In conclusion, our findings support the idea that green tea or coffee consumption does not have a substantial impact on pancreatic cancer risk in general.