Lipedema and Dercum's Disease: A New Application of Bioimpedance
Lipedema and Dercum's Disease: A New Application of Bioimpedance
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DOI：
10.1089/lrb.2019.0011
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发表时间：
2019-08-13
影响因子：
1.4
通讯作者：
Herbst, Karen L.
中科院分区：
文献类型：
--
作者：
Crescenzi, Rachelle;Donahue, Paula M. C.;Herbst, Karen L.
背景：脂肪水肿和Dercum病（DD）是一种特征不完全的脂肪组织疾病，需要客观的疾病特征测量来帮助鉴别诊断。我们假设，在这些条件下，流体特性（量化为上肢和下肢的组织水生物阻抗）存在区域差异。方法和结果：女性（累积n = 156）患有脂肪水肿（n = 110）， DD (n = 25)，或没有脂肪疾病，年龄和体重指数与早期脂肪水肿患者（即对照组n = 21）相匹配。应用生物阻抗谱（BIS）测量手臂和腿部的阻抗值，指示细胞外水位。记录每条肢体的阻抗值，以及腿臂阻抗比。应用回归模型评估阻抗与疾病临床指标之间的假设关系（显著性标准：双侧p < 0.05）。(1)与低阶段脂肪水肿患者相比，高阶段脂肪水肿患者的腿部细胞外水更高（p = 0.03）；(2)与DD患者相比，高阶段脂肪水肿患者的腿臂阻抗比更高（p = 0.03）
Background: Lipedema and Dercum's disease (DD) are incompletely characterized adipose tissue diseases, and objective measures of disease profiles are needed to aid in differential diagnosis. We hypothesized that fluid properties, quantified as tissue water bioimpedance in the upper and lower extremities, differ regionally between these conditions. Methods and Results: Women (cumulative n = 156) with lipedema (n = 110), DD (n = 25), or without an adipose disease matched for age and body mass index to early stage lipedema patients (i.e., controls n = 21) were enrolled. Bioimpedance spectroscopy (BIS) was applied to measure impedance values in the arms and legs, indicative of extracellular water levels. Impedance values were recorded for each limb, as well as the leg-to-arm impedance ratio. Regression models were applied to evaluate hypothesized relationships between impedance and clinical indicators of disease (significance criteria: two-sided p < 0.05). Higher extracellular water was indicated (i) in the legs of patients with higher compared with lower stages of lipedema (p = 0.03), (ii) in the leg-to-arm impedance ratio in patients with lipedema compared with patients with DD (p