Sensitivity of MRI-guided near-infrared spectroscopy clinical breast exam data and its impact on diagnostic performance
Sensitivity of MRI-guided near-infrared spectroscopy clinical breast exam data and its impact on diagnostic performance
复制标题
MRI引导近红外光谱临床乳腺检查数据的敏感性及其对诊断性能的影响
DOI：
10.1364/boe.5.003103
复制
发表时间：
2014-09-01
影响因子：
3.4
通讯作者：
Paulsen, Keith D.
中科院分区：
文献类型：
--
作者：
Mastanduno, Michael A.;Xu, Junqing;Paulsen, Keith D.
在本研究中，使用空间灵敏度指标分析了44例计划进行手术切除的患者（最终诊断为16例良性和28例恶性）的乳腺MRI引导近红外光谱（NIRS）检查数据，以量化从并行MRI扫描中获得的询问肿瘤感兴趣区域的光学测量的充分性。沿着位置敏感性，光谱先验的结合和适当的正则化参数的选择在图像重建被认为是，并发现影响恢复图像的诊断准确性。一旦优化，MRI/NIRS数据能够通过总血红蛋白（p = 0.0037）和组织光学指数（p = 0.00019）区分恶性和良性病变，但要求光学测量数据对每个病变的相对空间灵敏度高于1%。在重建过程中实施的光谱约束，需要获得统计学显着的诊断信息，从图像的水，脂质，和组织光学指数（TOI）。这些结果证实了对具有乳房的均匀空间覆盖同时仍然能够适应乳房尺寸的正常范围的光学系统的需求。(C)2014年美国光学学会
In this study, data from breast MRI-guided near infrared spectroscopy (NIRS) exams delivered to 44 patients scheduled for surgical resection (ending in 16 benign and 28 malignant diagnoses) were analyzed using a spatial sensitivity metric to quantify the adequacy of the optical measurements for interrogating the tumor region of interest, as derived from the concurrent MRI scan. Along with positional sensitivity, the incorporation of spectral priors and the selection of an appropriate regularization parameter in the image reconstruction were considered, and found to influence the diagnostic accuracy of the recovered images. Once optimized, the MRI/NIRS data was able to differentiate the malignant from benign lesions through both total hemoglobin (p = 0.0037) and tissue optical index (p = 0.00019), but required the relative spatial sensitivity of the optical measurement data to each lesion to be above 1%. Spectral constraints implemented during the reconstruction were required to obtain statistically significant diagnostic information from images of H2O, lipids, and Tissue Optical Index (TOI). These results confirm the need for optical systems that have homogenous spatial coverage of the breast while still being able to accommodate the normal range of breast sizes. (C) 2014 Optical Society of America