Immunity toward H1N1 influenza hemagglutinin of historical and contemporary strains suggests protection and vaccine failure
Immunity toward H1N1 influenza hemagglutinin of historical and contemporary strains suggests protection and vaccine failure
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DOI：
10.1038/srep01698
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发表时间：
2013-04-23
影响因子：
4.6
通讯作者：
Kelvin, Alyson A.
中科院分区：
文献类型：
--
作者：
Huang, Stephen S. H.;Lin, Zhen;Kelvin, Alyson A.
过去 100 年 H1N1 甲型流感疫情的演变非常有趣且极其复杂，而 H1N1 遗传漂变的细节仍然未知。在此，我们研究了历史上重要的 H1N1 病毒株的临床特征和免疫交叉反应性。我们用 1943 年、1947 年、1977 年、1986 年、1999 年和 2009 年的 H1N1 病毒株感染雪貂，结果显示每种病毒株都产生了独特的临床特征。我们发现具有相似 HA 序列的病毒之间存在显着的交叉反应。有趣的是，A/FortMonmouth/1/1947 抗血清与 A/USSR/90/1977 病毒发生交叉反应，该病毒被认为是 1947 年重新出现的病毒。重要的是，我们没有显示交叉反应性的免疫学数据可以推断为过去 H1N1 流感疫苗的失败，即。 1947 年、1986 年和 2009 年。我们的研究结果共同有助于阐明过去 100 年来发生的 H1N1 免疫遗传变化以及 H1N1 进化引起的免疫反应。这项工作将促进未来流感治疗方法和预防措施（例如流感疫苗）的开发。
Evolution of H1N1 influenza A outbreaks of the past 100 years is interesting and significantly complex and details of H1N1 genetic drift remains unknown. Here we investigated the clinical characteristics and immune cross-reactivity of significant historical H1N1 strains. We infected ferrets with H1N1 strains from 1943, 1947, 1977, 1986, 1999, and 2009 and showed each produced a unique clinical signature. We found significant cross-reactivity between viruses with similar HA sequences. Interestingly, A/FortMonmouth/1/1947 antisera cross-reacted with A/USSR/90/1977 virus, thought to be a 1947 resurfaced virus. Importantly, our immunological data that didn't show cross-reactivity can be extrapolated to failure of past H1N1 influenza vaccines, ie. 1947, 1986 and 2009. Together, our results help to elucidate H1N1 immuno-genetic alterations that occurred in the past 100 years and immune responses caused by H1N1 evolution. This work will facilitate development of future influenza therapeutics and prophylactics such as influenza vaccines.