Atypical brain activation patterns during a face-to-face joint attention game in adults with autism spectrum disorder.
Atypical brain activation patterns during a face-to-face joint attention game in adults with autism spectrum disorder.
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DOI：
10.1002/hbm.22086
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发表时间：
2013-10
影响因子：
4.8
通讯作者：
Saxe R
中科院分区：
文献类型：
--
作者：
Redcay E;Dodell-Feder D;Mavros PL;Kleiner M;Pearrow MJ;Triantafyllou C;Gabrieli JD;Saxe R
联合注意行为包括发起一个自己的和响应另一个对物体、人或主题的联合注意的出价。自闭症儿童的联合注意力能力普遍不典型，与语言和社交能力的发展相关，并将自闭症儿童与其他发育障碍儿童区分开来。尽管这些行为很重要，但自闭症患者联合注意力的神经相关性仍然不清楚。这种数据的缺乏可能是由于在实时社交互动期间获取数据的固有挑战。我们使用了一种新颖的实验装置，在fMRI数据采集过程中，参与者与实验者进行交互式面对面的联合注意力游戏。启动（IJA）和响应（RJA）联合注意行为进行了检查，以及一个单独的注意（SA）控制条件。参与者包括患有自闭症谱系障碍（ASD）的成年人（n=13），平均年龄和性别匹配的神经典型组（n=14）和一组单独的神经典型成年人（n=22）。在RJA期间，与SA条件相比，在社会认知脑区域（包括背内侧前额叶皮层（dMPFC）和右后上级颞沟（pSTS））之间发现了显著差异。感兴趣的区域分析显示，ASD患者左pSTS和dMPFC内的联合注意和控制条件之间缺乏信号分化。在pSTS中，这种缺乏分化的特征在于联合注意期间的激活减少和单独注意期间的相对过度激活。这些研究结果表明，可能失败的STS和dMPFC内的发展神经专业化的联合注意ASD。
Joint attention behaviors include initiating one's own and responding to another's bid for joint attention to an object, person, or topic. Joint attention abilities in autism are pervasively atypical, correlate with development of language and social abilities, and discriminate children with autism from other developmental disorders. Despite the importance of these behaviors, the neural correlates of joint attention in individuals with autism remain unclear. This paucity of data is likely due to the inherent challenge of acquiring data during a real-time social interaction. We used a novel experimental set-up in which participants engaged with an experimenter in an interactive face-to-face joint attention game during fMRI data acquisition. Both initiating (IJA) and responding to (RJA) joint attention behaviors were examined as well as a solo attention (SA) control condition. Participants included adults with autism spectrum disorder (ASD) (n=13), a mean age- and sex-matched neurotypical group (n=14), and a separate group of neurotypical adults (n=22). Significant differences were found between groups within social-cognitive brain regions, including dorsal medial prefrontal cortex (dMPFC) and right posterior superior temporal sulcus (pSTS), during the RJA as compared to SA conditions. Region of interest analyses revealed a lack of signal differentiation between joint attention and control conditions within left pSTS and dMPFC in individuals with ASD. Within the pSTS, this lack of differentiation was characterized by reduced activation during joint attention and relative hyper-activation during solo attention. These findings suggest a possible failure of developmental neural specialization within the STS and dMPFC to joint attention in ASD.
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DOI：
10.1111/j.2044-835x.1989.tb00793.x
发表时间：
1989-06-01
影响因子：
2.3
作者：
BARONCOHEN, S
通讯作者：
BARONCOHEN, S
影响因子：
3.4
作者：
Farroni, Teresa;Massaccesi, Stefano;Johnson, Mark H.
通讯作者：
Johnson, Mark H.
影响因子：
3.9
作者：
Lord, C;Risi, S;Rutter, M
通讯作者：
Rutter, M
婴儿早期的选择性前额皮质对共同注意力的反应。
影响因子：
3.3
作者：
Grossmann, Tobias;Johnson, Mark H.
通讯作者：
Johnson, Mark H.
早期的皮质专业化，用于人类婴儿面对面交流。
DOI：
10.1098/rspb.2008.0986
发表时间：
2008-12-22
期刊：
Proceedings. Biological sciences
影响因子：
--
作者：
Grossmann T;Johnson MH;Lloyd-Fox S;Blasi A;Deligianni F;Elwell C;Csibra G
通讯作者：
Csibra G