Prospective evaluation of the utility of cross-matching prior to first transfusion in cats: 101 cases
Prospective evaluation of the utility of cross-matching prior to first transfusion in cats: 101 cases
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DOI：
10.1111/jsap.13124
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发表时间：
2020-03-04
影响因子：
1.6
通讯作者：
Chan, D. L.
中科院分区：
文献类型：
--
作者：
Humm, K. R.;Chan, D. L.
目标：（1）使用两种交叉配血方法评估初次接受猫输血者中交叉配血不相容性的频率，（2）测量交叉配血不相容性对输血后红细胞压积变化的影响，（3）评估猫急性输血反应和输血错误的频率，以及（4）评估交叉配血不相容性对输血反应可能性的影响。本观察性研究前瞻性招募了一家兽医教学医院的匹配输血。玻片凝集法和商业检测均用于主要和次要交叉配血。我们测量增加红细胞压积在输血后12小时相对于每个受体体重的红细胞的质量，并记录输血reactions.Results共101只猫。使用玻片凝集法时，交叉配型不相容性很常见（主要和次要不相容性分别为27%和10%），但商业检测不太常见（主要和次要不相容性均为4%）。任何方法的交叉配血不相容性与红细胞压积变化方面的输血效果降低无关。20只猫发生输血反应，最常见的是发热性非溶血性输血反应（n = 9）和溶血性输血反应（n = 7）。临床意义输血反应相当常见，但与死亡率增加无关。使用交叉配血相容性血液在12小时时不会导致PCV更大的增加。商业测试可以预测溶血性输血反应。
Objectives To: (1) assess the frequency of crossmatch incompatibility in naive feline blood transfusion recipients using two crossmatching methods, (2) measure the effect of crossmatch incompatibility on change in packed cell volume following transfusion, (3) assess the frequency of acute transfusion reactions and errors in blood transfusions in cats and (4) assess the impact of crossmatch incompatibility on the likelihood of transfusion reactions.Materials and Methods Cats being administered a first AB-matched transfusion in a veterinary teaching hospital were prospectively recruited for this observational study. A slide agglutination method and a commercial test were both used for major and minor crossmatching. We measured increase in packed cell volume at 12 hours after transfusion relative to the mass of red blood cells given per recipient bodyweight and recorded transfusion reactions.Results A total of 101 cats was included. Crossmatch incompatibility was common using the slide agglutination method (27% and 10% major and minor incompatibility, respectively), but less common with the commercial test (major and minor incompatibility both 4%). Crossmatch incompatibility with any method was not associated with less effective transfusion in terms of change in packed cell volume. Transfusion reactions occurred in 20 cats, most commonly febrile non-haemolytic transfusion reactions (n = 9) and haemolytic transfusion reactions (n = 7). The commercial test appeared to be most specific for predicting haemolytic transfusion reactions.Clinical Significance Transfusion reactions were fairly common but not associated with increased mortality. Use of crossmatch-compatible blood did not lead to a greater increase in PCV at 12 hours. The commercial test may predict a haemolytic transfusion reaction.