Receptor Organization Determines the Limits of Single-Cell Source Location Detection
Receptor Organization Determines the Limits of Single-Cell Source Location Detection
复制标题
受体组织决定单细胞源位置检测的极限
DOI：
10.1103/physrevlett.125.018102
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发表时间：
2020
影响因子：
8.6
通讯作者：
Miles, Christopher E.
中科院分区：
文献类型：
--
作者：
Lawley, Sean D.;Lindsay, Alan E.;Miles, Christopher E.
许多类型的细胞需要能够根据扩散信号分子到达细胞表面受体来精确定位外部刺激的位置。这些受体的组织（数量和空间配置）如何限制细胞推断源位置的能力？在球形细胞的理想化场景中，我们应用渐近分析来计算各个受体之间的分裂概率，并制定信息论框架来量化受体组织的作用。受体的簇结构在检测与簇对齐的源方面具有优势，这表明单细胞源推断可能存在多尺度机制。
Many types of cells require the ability to pinpoint the location of an external stimulus from the arrival of diffusing signaling molecules at cell-surface receptors. How does the organization (number and spatial configuration) of these receptors shape the limit of a cell’s ability to infer the source location? In the idealized scenario of a spherical cell, we apply asymptotic analysis to compute splitting probabilities between individual receptors and formulate an information-theoretic framework to quantify the role of receptor organization. Clustered configurations of receptors provide an advantage in detecting sources aligned with the clusters, suggesting a possible multiscale mechanism for single-cell source inference.