A 4DCT imaging-based breathing lung model with relative hysteresis.
A 4DCT imaging-based breathing lung model with relative hysteresis.
复制标题
具有相对滞后的基于 4DCT 成像的呼吸肺模型。
DOI：
10.1016/j.jcp.2016.08.039
复制
发表时间：
2016
影响因子：
4.1
通讯作者：
Lin,Ching-Long
中科院分区：
文献类型：
--
作者：
Miyawaki,Shinjiro;Choi,Sanghun;Hoffman,EricA;Lin,Ching-Long
为了再现真实的呼吸道运动和气流，作者开发了基于四维(4D、空间和时间)动态CT图像的变形肺计算流体动力学(CFD)模型。受控潮气量呼吸的13个时间点被用来解释人类志愿者真实的和不规则的肺运动。针对基于4DCT的呼吸道不规则运动的特点，提出了一种呼吸过程中气道表面变形的最优插值方法，并实现了一种基于计算固体力学的移动网格算法来生成平滑变形的气道网格。此外，我们基于多幅图像和单幅图像为两种模型开发了生理上真实的气流边界条件。此外，我们还研究了基于一个或两个动态或静态图像的简化模型。通过将这些简化模型与基于13幅动态图像的模型进行比较，我们研究了肺结构相对于肺体积、肺变形和成像方法(即动态扫描和静态扫描)的相对滞后对CFD预测的压降的影响。由于气流分布和气道几何形状的不同，成像方法对压降的影响为24个百分点。
To reproduce realistic airway motion and airflow, the authors developed a deforming lung computational fluid dynamics (CFD) model based on four-dimensional (4D, space and time) dynamic computed tomography (CT) images. A total of 13 time points within controlled tidal volume respiration were used to account for realistic and irregular lung motion in human volunteers. Because of the irregular motion of 4DCT-based airways, we identified an optimal interpolation method for airway surface deformation during respiration, and implemented a computational solid mechanics-based moving mesh algorithm to produce smooth deforming airway mesh. In addition, we developed physiologically realistic airflow boundary conditions for both models based on multiple images and a single image. Furthermore, we examined simplified models based on one or two dynamic or static images. By comparing these simplified models with the model based on 13 dynamic images, we investigated the effects of relative hysteresis of lung structure with respect to lung volume, lung deformation, and imaging methods, i.e., dynamic vs. static scans, on CFD-predicted pressure drop. The effect of imaging method on pressure drop was 24 percentage points due to the differences in airflow distribution and airway geometry.