A model for neuronal competition during development
A model for neuronal competition during development
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DOI：
10.1126/science.1152677
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发表时间：
2008-04-18
期刊：
影响因子：
56.9
通讯作者：
Ginty, David D.
中科院分区：
文献类型：
--
作者：
Deppmann, Christopher D.;Mihalas, Stefan;Ginty, David D.
我们报告说，交感神经元之间的生存发展竞争是至关重要的依赖于敏化过程发起的目标神经支配和介导的一系列反馈回路。靶源性神经生长因子（NGF）促进其自身受体TrkA在小鼠和大鼠神经元中的表达，并延长TrkA介导的信号。NGF还控制脑源性神经营养因子和神经营养素-4的表达，其通过受体p75可以杀死具有低逆行NGF-TrkA信号传导的邻近神经元，而具有高NGF-TrkA信号传导的神经元受到保护.任何一个反馈回路的扰动都会破坏竞争的动态。我们认为，三个目标启动的事件是必不可少的快速和强大的竞争之间的神经元：敏化，旁分泌凋亡信号，并保护这种影响。
We report that developmental competition between sympathetic neurons for survival is critically dependent on a sensitization process initiated by target innervation and mediated by a series of feedback loops. Target- derived nerve growth factor ( NGF) promoted expression of its own receptor TrkA in mouse and rat neurons and prolonged TrkA- mediated signals. NGF also controlled expression of brain- derived neurotrophic factor and neurotrophin- 4, which, through the receptor p75, can kill neighboring neurons with low retrograde NGF- TrkA signaling whereas neurons with high NGF- TrkA signaling are protected. Perturbation of any of these feedback loops disrupts the dynamics of competition. We suggest that three target- initiated events are essential for rapid and robust competition between neurons: sensitization, paracrine apoptotic signaling, and protection from such effects.