A pilot study on the changes in immunity after ACTH therapy in patients with West syndrome
A pilot study on the changes in immunity after ACTH therapy in patients with West syndrome
复制标题
DOI：
10.1016/j.braindev.2008.11.007
复制
发表时间：
2009-11-01
影响因子：
1.7
通讯作者：
Matsuishi, Toyojiro
中科院分区：
文献类型：
--
作者：
Ohya, Takashi;Nagai, Toshisaburo;Matsuishi, Toyojiro
促肾上腺皮质激素（ACTH）一直是治疗西氏综合征的一线药物，尽管该疗法有各种不良反应。ACTH抑制对多种细菌、病毒、原生动物和真菌的抵抗力。在日本，ACTH治疗后，各种疫苗接种的时间被推迟，因为免疫系统被认为受到大约6个月的影响。然而，ACTH油对免疫系统的影响持续时间尚不清楚。因此，我们检查了ACTH治疗前后免疫水平的变化。我们测量了白细胞计数、淋巴细胞计数、T/B细胞计数、CD4（+）和CD8(+) T细胞计数、CD4 /8比值、PHA或Con-A淋巴细胞囊胚转化，以及ACTH治疗前、治疗后立即、治疗后1、31、16和12个月的IgA、IgM和IgG水平。淋巴细胞计数和CD4(+) T细胞计数在治疗后1个月和3个月均显著下降，即使在治疗后6个月和12个月也没有恢复到原来的水平，但这些水平恢复到正常范围内（95%置信区间内）。ACTH治疗后免疫球蛋白水平未发生变化。促肾上腺皮质激素治疗后辅助性T细胞比细胞毒性T细胞更受抑制。(C) 2008 Elsevier B.V.版权所有
Adrenocorticotropic hormone (ACTH) has been the first-line drug for the treatment ofWest syndrome, although the therapy has various adverse effects. ACTH depresses resistance to a variety of bacterial, viral, protozoal, and fungal agents. The timing of the various vaccinations is delayed after ACTH therapy in Japan, because the immune system is believed to be affected for approximately 6 months. However, the duration of the effect of ACTH oil the immune system is not known. Therefore, we examined changes in the immunity levels before and after ACTH therapy. We measured white blood cell counts, lymphocyte counts, T/B cell counts, CD4(+) and CD8(+) T cell counts, CD 4/8 ratio, lymphocyte blastoid transformation by PHA or Con-A, and the levels of IgA, IgM, and IgG before, immediately after, and 1, 31 6, and 12 months after ACTH therapy. The lymphocyte counts and CD4(+) T cell counts were significantly decreased immediately after and at I and 3 months after the therapy, and did not return to the previous levels even at 6 months and 12 months after ACTH treatment, however, these levels returned to within normal limits (within the 95% confidence interval). Immunoglobulin levels did not change after the ACTH therapy. Helper T cells were more depressed than cytotoxic T cells after ACTH therapy. (C) 2008 Elsevier B.V. All rights reserved.