The relationship between retinal pigment epithelium and the choriocapillaris.
The relationship between retinal pigment epithelium and the choriocapillaris.
复制标题
视网膜色素上皮和脉络膜毛细血管之间的关系。
DOI：
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
S. Gartner
中科院分区：
文献类型：
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作者：
P. Henkind;S. Gartner
视网膜色素变性（RP）患者的组织病理学检查发现，脉络膜毛细血管（CC）缺失。在不存在上覆视网膜色素上皮（RPE）的区域中观察到。我们的材料的分析，以及与RP和相关实体，以及一些其他眼底疾病的文献综述，表明CC的消失是继发于REP变性。使用静脉注射碘酸钠的实验模型在兔子中产生了类似的事件序列。我们认为RPE调节CC的结构和功能。可能存在正常CC窗形成和维持所需的可扩散的生化血管调节因子（VMF），其由正常RPE释放，并作用于血管内皮。缺乏VME导致内皮细胞失去其窗孔，血管闭塞。这种RPE-CC交互是RPE的另一个方面，需要深入研究。
Absence of the choriocapillaris (CC) was observed histopathologically in human eyes with retinitis pigmentosa (RP). It was noted in areas where the overlying retinal pigment epithelium (RPE) was absent. Analysis of our material, as well as a review of the literature dealing with RP and related entities, as well as a number of other fundus disorders, suggested that the disappearance of the CC is secondary to REP degeneration. An experimental model using intravenous sodium iodate produced a similar sequence of events in the rabbit. We suggest that the RPE modulates structure and function of the CC. There is possibly a diffusable biochemical vascular modulation factor (VMF) which is required for normal CC fenestrae formation and maintenance, which is liberated by the normal RPE, and acts upon the vascular endothelium. Lack of VME causes the endothelium to lose its fenestrae and the vessel to occlude. This RPE-CC interaction is a further facet of the RPE which requires exploration in depth.