RENAL-CELL CARCINOMA IN NEW-ZEALAND - A NATIONAL SURVIVAL STUDY
RENAL-CELL CARCINOMA IN NEW-ZEALAND - A NATIONAL SURVIVAL STUDY
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DOI：
10.1016/0090-4295(94)90070-1
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发表时间：
1994-03-01
期刊：
影响因子：
2.1
通讯作者：
NACEY, JN
中科院分区：
文献类型：
--
作者：
DELAHUNT, B;BETHWAITE, P;NACEY, JN
Objective.通过对人群癌症登记的病例报告，确定肾细胞癌（RCC）的临床和病理预后因素。检索了1976年至1986年间向新西兰癌症登记处报告的所有RCC病例，并分析了数据以确定预后重要性参数。结果。在11年中，新西兰癌症登记处报告了1，308例RCC（66.7%男性和33.3%女性）。年龄标准化发病率为3.78/105人-年，在研究期间未显示出显著趋势。最大的种族群体之间的发病年龄有很大的差别（毛利人52.2岁;非毛利人63.2岁），这是由于毛利人中的诱发危险因素增加所致，五年的精算生存率为42.4%，在1990年12月的随访中，63%的病人报告死亡。在这一系列研究中，患者性别（女性>男性）、肿瘤偏侧性（右侧>左侧）、分期（肾内>局限性>播散性）、分级（1 > 2 > 3 > 4）和治疗方式（手术>非手术）被认为是重要的预后因素，尽管只有肿瘤分期和治疗方式具有独立意义。肿瘤偏侧性仅对II期（局部）手术治疗的肿瘤具有预后意义。结论。研究结果强调了肿瘤分期作为RCC预后参数的重要性。偏侧性对局部手术治疗肿瘤的预后意义表明，根治性肾切除术不太可能导致左侧RCC的肿瘤清除比右侧肿瘤。
Objective. To determine clinical and pathologic prognostic factors for renal cell carcinoma (RCC) using cases reported to a population-based cancer registry.Methods. All cases of RCC reported to the New Zealand Cancer Registry between 1976 and 1986 were retrieved and data analyzed to determine parameters of prognostic importance.Results. In eleven years, 1,308 cases of RCC (66.7% males and 33.3% females) were reported to the New Zealand Cancer Registry. The age-standardized incidence rate was 3.78 per 105 person-years and showed no significant trend over the period of the study. There was a significant difference in the age at presentation between the largest racial groups (Maori 52.2 years; non-Maori 63.2 years), which is accounted for by increased predisposing risk factors among Maori.The five-year actuarial survival rate was 42.4 percent with 63 percent of patients reported dead in follow-up to December 1990. In the series, patient gender (female > male), tumor laterality (right > left), stage (intrarenal > localized > disseminated), grade (1 > 2 > 3 > 4), and treatment modality (surgery > nonsurgery) were found to be significant prognostic factors, although only tumor stage and treatment modality were of independent significance. Tumor laterality was of prognostic significance for Stage II (localized) surgically treated tumors only.Conclusions. The results of the study emphasize the paramount importance of tumor stage as a prognostic parameter for RCC. The prognostic significance of laterality for localized, surgically treated tumors suggests that radical nephrectomy is less likely to result in tumor clearance for left-sided RCC than for tumors on the right side.