New-generation small animal positron emission tomography system for molecular imaging
New-generation small animal positron emission tomography system for molecular imaging
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DOI：
10.1117/1.jmi.4.1.011008
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发表时间：
2017-01-01
影响因子：
2.4
通讯作者：
Levin, Craig S.
中科院分区：
文献类型：
--
作者：
Abbaszadeh, Shiva;Levin, Craig S.
分子成像的下一代发现需要具有高空间分辨率和高灵敏度的正电子发射断层扫描（PET）系统来可视化和量化低浓度的分子探针。这项工作的目标是组装和探索这样一个系统。我们利用碲化镉锌（CZT）实现了高空间分辨率、三维相互作用定位和优异的能量分辨率。在四边面板几何结构中，CZT晶体以最小间隙为50 μ m的边缘配置排列，以获得优越的光子灵敏度。开发的CZT探测器和读出电子设备被放大，以完成最终PET系统的重要部分。优化了转向电极偏置和时间测量模拟信号的幅值，提高了性能。468通道的能量分辨率（511 keV）为7.43 +/- 1.02%全宽度半最大（FWHM）。空间分辨率为0.76±0.1 mm FWHM。6个CZT晶体与其他6个CZT晶体重合的时间分辨率为37 ns。该系统具有较高的能量和空间分辨率以及相对较低的小动物成像随机率，有望在分子成像研究中发挥重要作用。(C) 2017年中国光学仪器工程师学会（SPIE）
The next generation of discoveries in molecular imaging requires positron emission tomography (PET) systems with high spatial resolution and high sensitivity to visualize and quantify low concentrations of molecular probes. The goal of this work is to assemble and explore such a system. We use cadmium zinc telluride (CZT) to achieve high spatial resolution, three-dimensional interaction positioning, and excellent energy resolution. The CZT crystals are arranged in an edge-on configuration with a minimum gap of 50 mu m in a four-sided panel geometry to achieve superior photon sensitivity. The developed CZT detectors and readout electronics were scaled up to complete significant portions of the final PET system. The steering electrode bias and the amplitude of the analog signals for time measurement were optimized to improve performance. The energy resolution (at 511 keV) over 468 channels is 7.43 +/- 1.02% full-width-at-half-maximum (FWHM). The spatial resolution is 0.76 +/- 0.1 mm FWHM. The time resolution of six CZT crystals in coincidence with six other CZT crystals is 37 ns. With high energy and spatial resolution and the relatively low random rate for small animal imaging, this system shows promise to be very useful for molecular imaging studies. (C) 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)